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Inhibitory Effects and Mechanisms of Colonic Electric Stimulation on Gastric and Rectal Tone in Conscious Dogs

  • Published:
Diseases of the Colon & Rectum

Purpose

Colonic electric stimulation has been shown to alter motor functions of the colon; however, its effects on other organs of the gut have been investigated rarely.

Methods

This study was performed in 12 dogs implanted with one pair of colonic serosal electrodes and a gastric cannula. Experiments were performed to study: 1) the effect of colonic electric stimulation on proximal gastric tone and compliance; 2) the effect of colonic electric stimulation on rectal tone and compliance; 3) the sympathetic mechanism involved in the effects of colonic electric stimulation on gastric/rectal tone. A computerized barostat was used to assess gastric/rectal tone and compliance.

Results

Colonic electric stimulation inhibited both gastric and rectal tone with a higher potency in gastric tone. Colonic electric stimulation reduced gastric but not rectal compliance. The inhibitory effect of colonic electric stimulation on gastric tone but not rectal tone was abolished by an adrenergic blockade, guanethidine.

Conclusions

Colonic electric stimulation inhibits both gastric and rectal tone with a higher potency in inhibiting gastric tone. Colonic electric stimulation reduces gastric but not rectal compliance. The inhibitory effect of colonic electric stimulation on gastric tone seems to be mediated by the sympathetic pathway.

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Authors and Affiliations

  1. Division of Gastroenterology, University of Texas Medical Branch, Galveston, Texas

    Shi Liu M.D. & J. D. Z. Chen Ph.D.

  2. Veterans Research Foundation, VA Medical Center, Oklahoma City, Oklahoma

    Yong Lei M.D. & J. D. Z. Chen Ph.D.

  3. GI Research, Route 0623, Room 221, Microbiology Building, 1108 The Strand, Galveston, Texas, 77555-0632, USA

    J. D. Z. Chen Ph.D.

Authors
  1. Shi Liu M.D.
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  2. Yong Lei M.D.
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  3. J. D. Z. Chen Ph.D.
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Correspondence to J. D. Z. Chen Ph.D..

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Liu, S., Lei, Y. & Chen, J.D.Z. Inhibitory Effects and Mechanisms of Colonic Electric Stimulation on Gastric and Rectal Tone in Conscious Dogs. Dis Colon Rectum 49, 1749–1754 (2006). https://doi.org/10.1007/s10350-006-0586-2

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  • DOI: https://doi.org/10.1007/s10350-006-0586-2

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