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Comparison of Characteristics and Survival of Colorectal Cancer Between Japanese-Americans in Hawaii and Native Japanese in Japan

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Diseases of the Colon & Rectum

Purpose

This study was designed to investigate whether characteristics, prognostic risk factors, and survival of colorectal cancer of Japanese-Americans in Hawaii are different from those of native Japanese in Japan.

Methods

Aretrospective review of patients with colorectal cancer surgically resected in single institutions in Hawaii and Japan from 1996 to 2002.

Results

A total of 410 Japanese-American patients (218 males; median age, 73 years) and621 native Japanese patients (382 males; median age, 65 years) were included. There were significant differences in age (P < 0.001), age distribution (P < 0.001), gender (P= 0.008), preoperative carcinoembryonic antigen (P < 0.001), and anatomic site distribution (P < 0.001). The tumor characteristics of Japanese-American patients wereclose to the general American population compared with the Surveillance, Epidemiology, and End Results data. There were no differences in tumor size, histologic grade, each of T, N, M status and TNM stage between the two groups. The overall five-year survival rates (Japanese-Americans, 75.5 percent; native Japanese, 76.2 percent; P = 0.55) and survival rates in each of four stratified stages were similar. Risk factors associated with survival were not different, except for carcinoembryonic antigen (P = 0.036).

Conclusions

In patients with colorectal cancer in Japanese-Americans in Hawaii, some of tumor characteristics have changed from those of native Japanese inJapan. However, there are no remarkable differences in prognostic factors and survival between the two groups. The present study suggests that certain changes of colorectal cancer characteristics that were seen in Japanese-American may occur in native Japanese in Japan in the near future, although the survivaloutcome of colorectal cancer may remain the same.

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Author information

Authors and Affiliations

  1. Department of Coloproctological Surgery, School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan

    Kazuhiro Sakamoto M.D., Ph.D., Tomoo Watanabe M.D., Seiya Hosoda M.D., Ph.D., Masahiko Sugano M.D., Ph.D., Yuichi Tomiki M.D., Ph.D. & Toshiki Kamano M.D., Ph.D.

  2. Department of Surgery, University of Hawaii, Honolulu, Hawaii, USA

    Kazuhiro Sakamoto M.D., Ph.D. & Junji Machi M.D., Ph.D.

  3. Oncology Data Registry, Kuakini Medical Center, Honolulu, Hawaii, USA

    Maria Prygrocki B.S., C.T.R.

Authors
  1. Kazuhiro Sakamoto M.D., Ph.D.
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  2. Junji Machi M.D., Ph.D.
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  3. Maria Prygrocki B.S., C.T.R.
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  4. Tomoo Watanabe M.D.
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  5. Seiya Hosoda M.D., Ph.D.
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  6. Masahiko Sugano M.D., Ph.D.
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  7. Yuichi Tomiki M.D., Ph.D.
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  8. Toshiki Kamano M.D., Ph.D.
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Corresponding author

Correspondence to Kazuhiro Sakamoto M.D., Ph.D..

Additional information

Read at the Clinical Congress of the American Collage of Surgeons, San Francisco, California, October 16 to 20, 2005.

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Cite this article

Sakamoto, K., Machi, J., Prygrocki, M. et al. Comparison of Characteristics and Survival of Colorectal Cancer Between Japanese-Americans in Hawaii and Native Japanese in Japan. Dis Colon Rectum 49, 50–57 (2006). https://doi.org/10.1007/s10350-005-0211-9

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  • DOI: https://doi.org/10.1007/s10350-005-0211-9

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