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Diseases of the Colon & Rectum

, Volume 48, Issue 9, pp 1700–1707 | Cite as

Implications of Pouchitis on the Functional Results Following Stapled Restorative Proctocolectomy

  • Ayman S. AbdelrazeqEmail author
  • Jonathan N. Lund
  • Stephen  H. Leveson
Original Contributions

PURPOSE

Pouchitis is the most frequent long-term complication of restorative proctocolectomy; its long-term consequences are inadequately described. This prospective study evaluates the effect of pouchitis on the functional results, general health perception, and patient satisfaction.

METHODS

A total of 100 consecutive patients who underwent stapled restorative proctocolectomy for ulcerative colitis were divided into three groups: no pouchitis, acute pouch-itis and chronic pouchitis. Functional results, general health perception, and satisfaction of each group at the latest review were compared only when patients were not symptomatic of active pouchitis.

RESULTS

Pouchitis occurred in 33 patients (17 acute and 16 chronic). There were no significant differences in the long-term functional results between the no pouchitis and acute pouchitis groups. Patients who experienced chronic pouchitis had a significant increase in bowel movements, looseness of stools, urgency, nocturnal seepage, perianal excoriation, and dietary restrictions (P < 0.05). They also had a worse perception of their general health (P < 0.05). Previous chronic pouchitis had no effect on continence, daytime soilage, or gas–feces discrimination. Most patients were satisfied, despite pouchitis, and would recommend the operation to someone else with ulcerative colitis.

CONCLUSIONS

Acute pouchitis is easily treated and results in minimal functional consequences. Even in the absence of clinically active pouchitis, patients who had suffered from chronic pouchitis had poorer functional results and general health perception. This may overshadow the benefits of restorative proctocolectomy. This finding suggests that acute and chronic pouchitis are distinct disease entities and chronic pouchitis may represent a persistent condition that displays episodic symptomatic exacerbation.

Key words

Pouchitis Restorative proctocolectomy Ulcerative colitis Anorectal function 

Notes

ACKNOWLEDGMENTS

The authors thank Dr. D. Leash, M.R.C.Path., for reviewing the pouch biopsies and the proctocolectomy histopathology, Mr. E. Grant from the Department of Clinical Effectiveness for assistance with statistical analysis, and Dr. R. Jeavons and Professor J. Clark of York University for reviewing the manuscript.

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Copyright information

© The American Society of Colon and Rectal Surgeons 2005

Authors and Affiliations

  • Ayman S. Abdelrazeq
    • 1
    Email author
  • Jonathan N. Lund
    • 1
  • Stephen  H. Leveson
    • 1
  1. 1.Colorectal Unit, Department of SurgeryYork HospitalYorkUnited Kingdom

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