Skip to main content


Log in

Choriocarcinoma of the colon

Report of a Case and Review of the Literature

  • Case Report
  • Published:
Diseases of the Colon & Rectum


Primary choriocarcinoma of the colon is a very rare tumor, with only six reported cases in the world literature, all but one of which was associated with an adjacent adenocarcinoma. This has led to the suggestion that colonic choriocarcinomas may arise from the more typical adenocarcinoma via a process of further dedifferentiation. This article reviews the above cases and adds a further case from a 73-year-old male in whom no associated adenocarcinoma could be found despite careful postmortem examination. This finding gives support to the hypothesis that, rather than arising as a result of further dedifferentiation of an existing tumor, primary choriocarcinomas may also develop de novo in the large intestine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others


  1. CA Moran S Suster (1997) ArticleTitlePrimary mediastinal choriocarcinomas Am J Surg Pathol 21 1007–1012

    Google Scholar 

  2. J Aparicio A Oltra . Martinez-Moragon C Llorca L Gomez-Aldaravi M Pastor (1996) ArticleTitleExtragonadal nongestational choriocarcinoma involving the lung Respiration 63 251–253

    Google Scholar 

  3. J Trubenbach PL Pereira PE Hupper et al. (1997) ArticleTitlePrimary choriocarcinoma of the pulmonary artery mimicking pulmonary embolism Br J Radiol 70 843–845

    Google Scholar 

  4. Y Imai T Kawabe M Takahashi et al. (1994) ArticleTitleA case of primary gastric choriocarcinoma and a review of the Japanese literature J Gastroenterol 29 642–646

    Google Scholar 

  5. M Coskun AM Agildere F Boyvat C Tarhan EA Niron (1998) ArticleTitlePrimary choriocarcinoma of the stomach and pancreas Eur Radiol. 8 1425–1428

    Google Scholar 

  6. B Ravi AK Dalal U Sharma JC Dhall (1997) ArticleTitleChoriocarcinoma of the small gut Acta Obstet Gynecol Scand 76 712–713

    Google Scholar 

  7. VM Lema BS Makanani T Saukila (1997) ArticleTitleAntepartum and postpartum haemorrhage in primary cervical choriocarcinoma East Afr Med J 74 600–602

    Google Scholar 

  8. S Deodhare CS Leung M Bullock (1996) ArticleTitleChoriocarcinoma associated with transitional cell carcinoma in-situ of the ureter Histopathology 28 363–365

    Google Scholar 

  9. SD Tinkler JT Roberts MC Robinson PD Ramsden (1996) ArticleTitlePrimary choriocarcinoma of the urinary bladder Clin Oncol (R Coll Radiol) 8 59–61

    Google Scholar 

  10. CH Park JD Reid (1980) ArticleTitleAdenocarcinoma of the colon with choriocarcinoma in its metastases Cancer 46 570–575

    Google Scholar 

  11. GK Nguyen (1982) ArticleTitleAdenocarcinoma of the sigmoid colon with focal choriocarcinoma metaplasia Dis Colon Rectum 25 230–234

    Google Scholar 

  12. NG Ordonez MA Luna (1984) ArticleTitleChoriocarcinoma of the colon Am J Gastroenterol 79 39–42

    Google Scholar 

  13. H Kubosawa K Nagao Y Kondo H Ishige N Inaba (1984) ArticleTitleCoexistence of adenocarcinoma and choriocarcinoma in the sigmoid colon Cancer 54 866–868

    Google Scholar 

  14. HM Lind P Haghighi (1986) ArticleTitleCarcinoembryonic antigen staining in choriocarcinoma Am J Clin Pathol 86 538–540

    Google Scholar 

  15. M Tokisue K Yasutake M Oya et al. (1996) ArticleTitleCoexistence of choriocarcinoma and adenocarcinoma in the rectum J Gastroenterol 31 431–436

    Google Scholar 

  16. H Watanabe H Tokuyama H Ohta et al. (1990) ArticleTitleExpression of placental alkaline phosphatase in gastric and colonic cancers. An immunohistochemical study using the prepared monoclonal antibody Cancer 66 2575–2582

    Google Scholar 

  17. E Campo A Palacin C Benasco E Quesada A Cardesa (1987) ArticleTitleHuman chorionic gonadotrophin in colorectal carcinoma. An immunohistochemical study Cancer 59 1611–1616

    Google Scholar 

Download references

Author information

Authors and Affiliations


About this article

Cite this article

Le, D.T., Austin, R.C., Payne, S.N. et al. Choriocarcinoma of the colon. Dis Colon Rectum 46, 264–266 (2003).

Download citation

  • Issue Date:

  • DOI: