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Application of Technetium-99m-Labeled Human Serum Albumin Scan to Assist Surgical Treatment of Protein-Losing Enteropathy in Cronkhite-Canada Syndrome: Report of A Case

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Diseases of the Colon & Rectum

Cronkhite-Canada syndrome is a rare form of nonhereditary gastrointestinal polyposis associated with ectodermal change and protein-losing enteropathy. Here we report a 63-year-old male presenting with diffuse gastrointestinal polyposis, onychodystrophy, cutaneous pigmentation, alopecia, diarrhea, hypoalbuminemia and lower leg edema. Technetium-99m-labeled human serum albumin scan confirmed the patient to have protein-losing enteropathy, which originated from the transverse and descending colon. Subtotal colectomy was performed. Albumin level and ectodermal change were gradually improved during three years of outpatient clinic follow-up. Based on our finding, Technetium-99m-labeled human serum albumin scintigraphy is helpful to localize the protein-losing origins and surgery is an effective treatment for Cronkhite-Canada syndrome with protein-losing enteropathy.

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Authors and Affiliations

  1. Department of Internal Medicine, Buddhist Dalin Tzu Chi General Hospital, Chia-Yi, Taiwan

    Kuo-Chih Tseng M.D.

  2. Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan

    Bor-Shyang Sheu M.D.

  3. Department of Surgery, National Cheng Kung University Hospital, Tainan, Taiwan

    Jenq-Chang Lee M.D.

  4. Department of Radiology, National Cheng Kung University Hospital, Tainan, Taiwan

    Hong-Ming Tsai M.D.

  5. Department of Nuclear Medicine, National Cheng Kung University Hospital, Tainan, Taiwan

    Nan-Tsing Chiu M.D.

  6. Department of Pathology, Chia-Yi Christian Hospital, Chia-Yi, Taiwan

    Yuan-Chang Dai M.D.

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  1. Kuo-Chih Tseng M.D.
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  2. Bor-Shyang Sheu M.D.
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  3. Jenq-Chang Lee M.D.
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  4. Hong-Ming Tsai M.D.
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  5. Nan-Tsing Chiu M.D.
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  6. Yuan-Chang Dai M.D.
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Correspondence to Jenq-Chang Lee M.D..

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Tseng, KC., Sheu, BS., Lee, JC. et al. Application of Technetium-99m-Labeled Human Serum Albumin Scan to Assist Surgical Treatment of Protein-Losing Enteropathy in Cronkhite-Canada Syndrome: Report of A Case. Dis Colon Rectum 48, 870–873 (2005). https://doi.org/10.1007/s10350-004-0836-0

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  • DOI: https://doi.org/10.1007/s10350-004-0836-0

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