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Postoperative Change of Mucosal Inflammation at Strictureplasty Segment in Crohn’s Disease: Cytokine Production and Endoscopic and Histologic Findings

  • Original Contribution
  • Published:
Diseases of the Colon & Rectum

PURPOSE

This study was designed to examine postoperative change of mucosal inflammation at strictureplasty segment in Crohn’s disease mainly by cytokine measurements.

METHODS

Patients who underwent strictureplasty for Crohn’s disease in the terminal ileum were investigated. Mucosal samples at the strictureplasty site were obtained during operation. At 3, 6, and 12 months after operation, biopsy specimens were taken from the strictureplasty site and macroscopically normal ileum at endoscopy. Mucosal cytokine concentrations were measured by enzyme-linked immunosorbent assay.

RESULTS

The mucosal concentrations of proinflammatory cytokines (interleukin-1β, interleukin-6, interleukin-8, and tumor necrosis factor-α) and anti-inflammatory mediator (interleukin-1 receptor antagonist) at the strictureplasty segment greatly increased at the time of operation. Interleukin-1β, interleukin-1 receptor antagonist, interleukin-6, interleukin-8, and tumor necrosis factor-α concentrations at the strictureplasty segment decreased during a 12-month period after operation. Twelve months after operation there was no significant difference in each cytokine concentration between the strictureplasty and macroscopically normal segments. The mucosal interleukin-1 receptor antagonist/interleukin-1β ratio at the strictureplasty segment increased during a 12-month period after operation. Twelve months after operation there was no significant difference in the ratio between the strictureplasty and macroscopically normal segments. The endoscopic and histologic severities of mucosal inflammation at the strictureplasty site also decreased; however, their findings were not normalized during the study.

CONCLUSIONS

During one year after strictureplasty for Crohn’s disease, cytokine production at the strictureplasty segment was decreased to the level of the macroscopically normal ileum and an imbalance between proinflammatory and anti-inflammatory cytokines was corrected.

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REFERENCES

  1. TC Dehn MG Kettlewell NJ Mortensen EC Lee DP Jewell (1989) ArticleTitleTen-year experience of strictureplasty for obstructive Crohn’s disease Br J Surg 76 339–41 Occurrence Handle1:STN:280:DyaL1M3kvVertw%3D%3D Occurrence Handle2720341

    CAS  PubMed  Google Scholar 

  2. VW Fazio JJ Tjandra IC Lavery JM Church JW Milsom JR Oakley (1993) ArticleTitleLong-term follow-up of strictureplasty in Crohn’s disease Dis Colon Rectum 36 355–61 Occurrence Handle1:STN:280:DyaK3s3gvFSrug%3D%3D Occurrence Handle8458261

    CAS  PubMed  Google Scholar 

  3. MP Spencer H Nelson BG Wolff RR Dozois (1994) ArticleTitleStrictureplasty for obstructive Crohn’s disease: the Mayo experience Mayo Clin Proc 69 33–6 Occurrence Handle1:STN:280:DyaK2c%2FpslSgtQ%3D%3D Occurrence Handle8271847

    CAS  PubMed  Google Scholar 

  4. JF Stebbing DP Jewell MG Kettlewell NJ Mortensen (1995) ArticleTitleLong-term results of recurrence and reoperation after strictureplasty for obstructing Crohn’s disease Br J Surg 82 1471–4 Occurrence Handle1:STN:280:DyaK287jsl2nug%3D%3D Occurrence Handle8535795

    CAS  PubMed  Google Scholar 

  5. RD Hurst F Michelassi (1998) ArticleTitleStrictureplasty for Crohn’s disease: techniques and long-term results World J Surg 22 359–63 Occurrence Handle10.1007/s002689900397 Occurrence Handle1:STN:280:DyaK1c7osVWiug%3D%3D Occurrence Handle9523517

    Article  CAS  PubMed  Google Scholar 

  6. T Yamamoto IM Bain RN Allan MR Keighley (1999) ArticleTitleAn audit of strictureplasty for small-bowel Crohn’s disease Dis Colon Rectum 42 797–803 Occurrence Handle1:STN:280:DyaK1MzgsV2msg%3D%3D Occurrence Handle10378605

    CAS  PubMed  Google Scholar 

  7. DW Dietz S Laureti SA Strong et al. (2001) ArticleTitleSafety and long-term efficacy of strictureplasty in 314 patients with obstructing small bowel Crohn’s disease J Am Coll Surg 192 330–8 Occurrence Handle1:STN:280:DC%2BD3M7osVGhtg%3D%3D Occurrence Handle11245375

    CAS  PubMed  Google Scholar 

  8. M Ligumsky PL Simon F Karmeli D Rachmilewitz (1989) ArticleTitleRole of interleukin 1 in inflammatory bowel disease-enhanced production during active disease Gut 31 686–9

    Google Scholar 

  9. YR Mahida K Wu DP Jewell (1989) ArticleTitleEnhanced production of interleukin-1β by mononuclear cells isolated from mucosa with active ulcerative colitis or Crohn’s disease Gut 30 835–8 Occurrence Handle1:CAS:528:DyaL1MXkslKgsrg%3D Occurrence Handle2787769

    CAS  PubMed  Google Scholar 

  10. J Brynskov N Tvede CB Andersen M Vilien (1992) ArticleTitleIncreased concentrations of interleukin-1B, interleukin-2, and soluble interleukin-2 receptors in endoscopical mucosal biopsy specimens with active inflammatory bowel disease Gut 33 55–8 Occurrence Handle1:STN:280:DyaK387lsFGgsQ%3D%3D Occurrence Handle1740278

    CAS  PubMed  Google Scholar 

  11. WE Pullman S Elsbury M Kobayashi AJ Hapel WF Doe (1992) ArticleTitleEnhanced mucosal cytokine production in inflammatory bowel disease Gastroenterology 102 529–37 Occurrence Handle1:STN:280:DyaK387itVersA%3D%3D Occurrence Handle1370662

    CAS  PubMed  Google Scholar 

  12. HC Reinecker M Steffen T Witthoeft et al. (1993) ArticleTitleEnhanced secretion of tumor necrosis factor-alpha, IL-6, and IL-1β by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn’s disease Clin Exp Immunol 94 174–81 Occurrence Handle1:CAS:528:DyaK3sXms1yltbw%3D Occurrence Handle8403503 Occurrence Handle10.1111/j.1365-2249.1993.tb05997.x

    Article  CAS  PubMed  Google Scholar 

  13. J-M Reimund C Wittersheim S Dumont et al. (1996) ArticleTitleMucosal inflammatory cytokine production by intestinal biopsies in patients with ulcerative colitis and Crohn’s disease J Clin Immunol 16 144–50 Occurrence Handle10.1007/BF01540912 Occurrence Handle1:CAS:528:DyaK28XjvVyktLs%3D Occurrence Handle8734357

    Article  CAS  PubMed  Google Scholar 

  14. K Ina K Kusugami T Yamaguchi et al. (1997) ArticleTitleMucosal interleukin-8 is involved in neutrophils migration and binding to extracellular matrix in inflammatory bowel disease Am J Gastroenterol 92 1342–6 Occurrence Handle1:STN:280:DyaK2svgsFOmuw%3D%3D Occurrence Handle9260803

    CAS  PubMed  Google Scholar 

  15. JS Hyams JE Fitzgerald N Wyzga et al. (1995) ArticleTitleRelationship of interleukin-1 receptor antagonist to mucosal inflammation in inflammatory bowel disease J Pediatr Gastroenterol Nutr 21 419–25 Occurrence Handle1:STN:280:DyaK287ivFKquw%3D%3D Occurrence Handle8583293 Occurrence Handle10.1097/00005176-199511000-00008

    Article  CAS  PubMed  Google Scholar 

  16. V Casini-Raggi L Kam YJ Chong C Fiocchi TT Pizarro F Cominelli (1995) ArticleTitleMucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease. A novel mechanism of chronic intestinal inflammation J Immunol 154 2434–40 Occurrence Handle1:CAS:528:DyaK2MXjsl2qu7k%3D Occurrence Handle7868909

    CAS  PubMed  Google Scholar 

  17. F Cominelli TT Pizarro (1996) ArticleTitleInterleukin-1 and interleukin-1 receptor antagonist in inflammatory bowel disease Aliment Pharmacol Ther 10(Suppl 2) 49–53

    Google Scholar 

  18. S Dionne ID D’Agata J Hiscott T Vanounou EG Seidman (1998) ArticleTitleColonic explant production of IL-1 and its receptor antagonist is imbalanced in inflammatory bowel disease (IBD) Clin Exp Immunol 112 435–42 Occurrence Handle10.1046/j.1365-2249.1998.00595.x Occurrence Handle1:STN:280:DyaK1czhtFGntA%3D%3D Occurrence Handle9649212

    Article  CAS  PubMed  Google Scholar 

  19. G Rogler T Andus (1998) ArticleTitleCytokines in inflammatory bowel disease World J Surg 22 382–9 Occurrence Handle10.1007/s002689900401 Occurrence Handle1:STN:280:DyaK1c7osVWhsA%3D%3D Occurrence Handle9523521

    Article  CAS  PubMed  Google Scholar 

  20. F Cominelli CC Nast A Duchini J Lee (1992) ArticleTitleRecombinant interleukin-1 receptor antagonist blocks the proinflammatory activity of endogenous interleukin-1 in rabbit immune colitis Gastroenterology 103 65–71 Occurrence Handle1:CAS:528:DyaK38XltV2rtL8%3D Occurrence Handle1535326

    CAS  PubMed  Google Scholar 

  21. TD Wardle L Hall LA Turnberg (1992) ArticleTitleUse of coculture of colonic mucosal biopsies to investigate the release of eicosanoids by inflamed and uninflamed mucosa from patients with inflammatory bowel disease Gut 33 1644–51 Occurrence Handle1:STN:280:DyaK3s7jvVCmsQ%3D%3D Occurrence Handle1487166

    CAS  PubMed  Google Scholar 

  22. EJ Breese CA Michie SW Nicholls et al. (1994) ArticleTitleTumor necrosis factor α-producing cells in the intestinal mucosa of children with inflammatory bowel disease Gastroenterology 106 1455–66 Occurrence Handle1:STN:280:DyaK2c3lt1Cquw%3D%3D Occurrence Handle8194690

    CAS  PubMed  Google Scholar 

  23. WR Best JM Becktel JW Singleton F Kern (1976) ArticleTitleDevelopment of a Crohn’s disease activity index: National Cooperative Crohn’s Disease Study Gastroenterology 70 439–44 Occurrence Handle1:STN:280:DyaE287hvVGmtg%3D%3D Occurrence Handle1248701

    CAS  PubMed  Google Scholar 

  24. MJ Blaster R Miller J Sachar J Singleton (1984) ArticleTitlePatients with active Crohn’s disease have elevated serum antibodies to antigens of seven enteric bacterial pathogens Gastroenterology 87 888–94 Occurrence Handle6468876

    PubMed  Google Scholar 

  25. J Cason CC Ainley RA Wolstencroft RP Thompson (1988) ArticleTitlePolymorphonuclear leucocytes in Crohn’s disease and ulcerative proctocolitis: association between enhanced adherence to nylon fibre and disease variables J Clin Pathol 41 241–6 Occurrence Handle1:STN:280:DyaL1c7pvVGlug%3D%3D Occurrence Handle3360954

    CAS  PubMed  Google Scholar 

  26. PH Harper EC Lee MG Kettlewell MK Bennett DP Jewell (1985) ArticleTitleRole of the faecal stream in the maintenance of Crohn’s colitis Gut 26 279–84 Occurrence Handle1:STN:280:DyaL2M7ivVGqsg%3D%3D Occurrence Handle3972275

    CAS  PubMed  Google Scholar 

  27. GN Tytgat CJ Mulder (1986) ArticleTitleThe aetiology of Crohn’s disease Int J Colorect Dis 1 188–92 Occurrence Handle10.1007/BF01648449 Occurrence Handle1:STN:280:DyaL2s3ot1SnsA%3D%3D

    Article  CAS  Google Scholar 

  28. KF Bruin DW Hommes J Jansen GN Tytgat J Wouter ten Cate SJ van Deventer (1995) ArticleTitleModulation of cytokine release from human monocytes by drugs used in the therapy of inflammatory bowel diseases Eur J Gastroenterol Hepatol 7 791–5 Occurrence Handle1:STN:280:DyaK287gtVSksw%3D%3D Occurrence Handle7496871

    CAS  PubMed  Google Scholar 

  29. D Rachmilewitz F Karmeli LW Schwartz PL Simon (1992) ArticleTitleEffect of aminophenols (5-ASA and 4-ASA) on colonic interleukin-1 generation Gut 33 929–32 Occurrence Handle1:CAS:528:DyaK38Xmt1KjtLs%3D Occurrence Handle1353743

    CAS  PubMed  Google Scholar 

  30. M Muñoz-Juárez T Yamamoto BG Wolff MR Keighley (2001) ArticleTitleWide-lumen stapled anastomosis vs. conventional end-to-end anastomosis in the treatment of Crohn’s disease Dis Colon Rectum 44 20–6 Occurrence Handle11805559

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Inflammatory Bowel Disease Center and Department of Surgery, Yokkaichi Social Insurance Hospital, Yokkaichi, Mie, Japan

    Takayuki Yamamoto M.D., Satoru Umegae M.D., Tatsushi Kitagawa M.D. & Koichi Matsumoto M.D.

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  1. Takayuki Yamamoto M.D.
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  2. Satoru Umegae M.D.
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  3. Tatsushi Kitagawa M.D.
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  4. Koichi Matsumoto M.D.
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Correspondence to Takayuki Yamamoto M.D..

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Yamamoto, T., Umegae, S., Kitagawa, T. et al. Postoperative Change of Mucosal Inflammation at Strictureplasty Segment in Crohn’s Disease: Cytokine Production and Endoscopic and Histologic Findings. Dis Colon Rectum 48, 749–757 (2005). https://doi.org/10.1007/s10350-004-0826-2

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  • DOI: https://doi.org/10.1007/s10350-004-0826-2

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