Diseases of the Colon & Rectum

, Volume 47, Issue 9, pp 1397–1402 | Cite as

Physiologic Effects of Bowel Preparation

  • Kathrine HolteEmail author
  • Kristine Grubbe Nielsen
  • Jan Lysgård Madsen
  • Henrik Kehlet
Original Contributions


Despite the universal use of bowel preparation before colonoscopy and colorectal surgery, the physiologic effects have not been described in a standardized setting. This study was designed to investigate the physiologic effects of bowel preparation.


In a prospective study, 12 healthy volunteers (median age, 63 years) underwent bowel preparation with bisacodyl and sodium phosphate. Fluid and food intake were standardized according to weight, providing adequate calorie and oral fluid intake. Before and after bowel preparation, weight, exercise capacity, orthostatic tolerance, plasma and extracellular volume, balance function, and biochemical parameters were measured.


Bowel preparation led to a significant decrease in exercise capacity (median, 9 percent) and weight (median, 1.2 kg). Plasma osmolality was significantly increased from 287 to 290 mmol kg−1, as well as increased phosphate and urea concentrations, whereas calcium and potassium concentrations decreased significantly after bowel preparation. No differences in plasma or extracellular volumes were seen. Orthostatic tolerance and balance function did not change after bowel preparation.


Bowel preparation has significant adverse physiologic effects, which may be attributed to dehydration. The majority of these findings is small and may not be of clinical relevance in otherwise healthy patients undergoing bowel preparation and following recommendations for oral fluid intake.


Bowel preparation Dehydration Exercise capacity Extracellular volume Plasma volume 


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Copyright information

© The American Society of Colon and Rectal Surgeons 2004

Authors and Affiliations

  • Kathrine Holte
    • 1
    Email author
  • Kristine Grubbe Nielsen
    • 1
  • Jan Lysgård Madsen
    • 2
  • Henrik Kehlet
    • 1
  1. 1.Department of Surgical GastroenterologyHvidovre University HospitalDenmark
  2. 2.Department of Clinical PhysiologyHvidovre University HospitalDenmark

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