Azaperone and sudden death of drive net-captured southern chamois

Abstract

The use of tranquilizers in the capture of southern chamois (Rupicapra pyrenaica) for scientific and/or management purposes (collection of samples, marking, translocations) was studied to improve animal welfare during capture operations. We used clinical findings and a statistical approach to analyze the causes of six incidences of mortality during captures using drive nets and tranquilizers in this species. Hematology and serum biochemistry, pathology, the use of tranquilizers and their dosages, the number of people involved in the capture of the chamois, and the location were all taken into account. The selection of candidate models to explain mortality was conducted using the theoretic information approach. Both observational findings and the models selected suggested that high doses of azaperone and to a lesser extent haloperidol had an effect on mortality rates. The higher mean serum lactate concentrations found in the chamois that died suggests that fatigue levels increased drug sensitivity and provoked the appearance of adverse effects, thereby increasing the probability of death. We conclude that butyrophenones—and especially azaperone—have a low safety margin in the southern chamois, contrary to what has been described for other species.

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References

  1. Arnemo JM, Negard T, Soli NE (1993) Deer farming in Norway. A review of the currently available drugs that can be used for immobilization, pain relief and anaesthesia. Norsk-Veterinaertidsskrift 105:517–521

    Google Scholar 

  2. Berducou C (1993) Chamois et isards: bilan des captures par filets, pièges et engins divers realisées en France au course des trente dernières années (1958–1989). In: Dubray D (ed) Techniques de capture et de marquage des ongulés sauvages. FDC de l'Hérault, Montpellier, pp 113–120

    Google Scholar 

  3. Booth NH (1988) Psychotropic agents. In: Booth NH, McDonald LE (eds) Veterinary pharmacology and therapeutics. Iowa State University Press, Ames, pp 363–395

    Google Scholar 

  4. Burnham KP, Anderson D (2002) Model selection and multimodel inference: a practical information-theoretical approach, 2nd edn. Springer, New York

    Google Scholar 

  5. Catusse M, Appolinaire J, Menaut P (1994) Traumatismes dus à la capture et à la détention d'isards. Bulletin Mensuel de l'Office National de la Chasse 190:22–25

    Google Scholar 

  6. Dematteis A, Giovo M, Rostagno F, Giordano O, Fina D, Menzano A, Tizzani P, Ficetto G, Rossi L, Meneguz PG (2010) Radio-controlled up-net enclosure to capture free-ranging Alpine chamois Rupicapra rupicapra. Eur J Wildl Res 56:535–539

    Article  Google Scholar 

  7. Ebedes H, Raath JP (1999) Use of tranquilizers in wild herbivores. In: Fowler ME, Miller RE (eds) Zoo and wild animal medicine. Current therapy 4. Saunders, Philadelphia, pp 575–585

    Google Scholar 

  8. Guyton AC, Hall JE (2000) Textbook of medical physiology, 10th edn. Saunders, Philadelphia

    Google Scholar 

  9. Hofmeyr JM (1981) The use of haloperidol as a long-acting neuroleptic in game capture operations. J S Afr Vet Assoc 52:273–282

    PubMed  CAS  Google Scholar 

  10. López-Olvera JR, Marco I, Montané J, Lavín S (2006a) Transport stress in Pyrenean chamois (Rupicapra pyrenaica) and its modulation with acepromacine. Vet J 172:347–355

    PubMed  Article  Google Scholar 

  11. López-Olvera JR, Marco I, Montané J, Lavín S (2006b) Haematological and serum biochemical values of Pyrenean chamois (Rupicapra pyrenaica). Vet Rec 158:479–484

    PubMed  Article  Google Scholar 

  12. López-Olvera JR, Marco I, Montané J, Casas-Díaz E, Lavín S (2007) Effects of acepromazine on the stress response in Pyrenean chamois (Rupicapra pyrenaica) captured by means of drive-nets. Rev Canad Rech Vet 71:41–51

    Google Scholar 

  13. López-Olvera JR, Marco I, Montané J, Casas-Díaz E, Mentaberre G, Lavín S (2009) Comparative evaluation of effort, capture and handling effects of drive nets to capture roe deer (Capreolus capreolus), Southern chamois (Rupicapra pyrenaica) and Spanish ibex (Capra pyrenaica). Eur J Wildl Res 55:193–202

    Article  Google Scholar 

  14. Meneguz PG, Rossi L, de Meneghi D (1994) Esperience di cattura de caprioli (Capreolus capreolus) e di camosci (Rupicapra rupicapra) con reti verticali. BIPAS 11:107–114

    Google Scholar 

  15. Mentaberre G, López-Olvera JR, Casas-Díaz E, Bach-Raich E, Marco I, Lavín S (2010a) Use of haloperidol and azaperone for stress control in roe deer (Capreolus capreolus) captured by means of drive-nets. Res Vet Sci 88:531–535

    PubMed  Article  CAS  Google Scholar 

  16. Mentaberre G, López-Olvera JR, Casas-Díaz E, Fernández-Sirera L, Marco I, Lavín S (2010b) Effects of azaperone and haloperidol on the stress response of drive-net captured Iberian ibexes (Capra pyrenaica). Eur J Wildl Res 56:757–764

    Article  Google Scholar 

  17. Mentaberre G, López-Olvera JR, Casas-Díaz E, Marco I, Lavín S (2010c) Assessing the usefulness of haloperidol and azaperone to reduce stress in drive-net captured Southern chamois (Rupicapra pyrenaica). J Wildl Dis 46:923–928

    PubMed  CAS  Google Scholar 

  18. Montané J, Marco I, López-Olvera JR, Manteca X, Lavín S (2002) Transport stress in roe deer (Capreolus capreolus): effect of a short-acting antipsychotic. Anim Welf 11:405–417

    Google Scholar 

  19. Montané J, Marco I, López-Olvera JR, Perpiñán D, Manteca X, Lavín S (2003) Effects of acepromazine on capture stress in roe deer (Capreolus capreolus). J Wildl Dis 39:375–386

    PubMed  Google Scholar 

  20. Montané J, Marco I, López-Olvera J, Rossi L, Manteca X, Lavín S (2007) Effect of acepromazine on the signs of capture stress in captive and free-ranging roe deer (Capreolus capreolus). Vet Rec 160:730–738

    PubMed  Article  Google Scholar 

  21. Plumb DC (2002) Veterinary drug handbook. 4th edn, Iowa State University Press, Ames, Iowa, USA

  22. R Development Core Team 2.13.0 (2011) R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria ISBN 3-900051-07-0, URL http://www.R-project.org. Accessed 1 July 2011

  23. Read MR, McCorkell RB (2002) Use of azaperone and zuclopenthixol acetate to facilitate translocation of white-tailed deer (Odocoileus virginianus). J Zoo Wildl Med 33:163–165

    PubMed  Google Scholar 

  24. Shury TK (1998) Use of azaperone with zuclopenthixol acetate for tranquilization of free ranging wood bison and immobilization with carfentanil and xylazine. In: Proceedings of the Annual Meeting of the American Association of Zoo Veterinarians: 408–409

  25. Spraker TR (1982) An overview of the pathophysiology of capture myopathy and related conditions that occur at the time of capture of wild animals. In: Nielsen L, Haigh JC, Fowler ME (eds) Chemical immobilization of North American wildlife. Wisconsin Humane Society, Milwaukee, pp 83–118

    Google Scholar 

  26. Spraker TR (1993) Stress and capture myopathy in artiodactyls. In: Fowler ME (ed) Zoo and wild animal medicine. Current therapy 3. Saunders, Philadelphia, pp 481–488

    Google Scholar 

  27. Swan GE (1993) Drugs used for the immobilization, capture, and translocation of wild animals. In: McKenzie AE (ed) The capture and care manual. Wildlife Decision Support Services and the South African Veterinary Foundation, Pretoria, pp 2–64

    Google Scholar 

  28. Zuur AF, Ieno EN, Walker NJ, Saveliev AA, Smith GM (2009) Mixed effects models and extensions in ecology with R. Springer, New York

    Book  Google Scholar 

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Acknowledgments

We are grateful to the staff of Cadí and Freser-Setcases NGR for their invaluable collaboration. We express our sincere regret at the loss of animal life. This research was funded by research projects CGL2009-11631 of Ministerio de Ciencia e Innovación and CGL2004-00330/BOS of the Comisión Interministerial de Ciencia y Tecnología (CICYT) and supported by the Direcció General de Medi Natural i Biodiversitat of the Department d'Agricultura, Ramaderia, Pesca, Alimentació i Medi Natural of the Generalitat de Catalunya. E. Serrano was supported by the Juan de la Cierva programme of the Ministerio de Ciencia e Innovación, Spain.

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Correspondence to Gregorio Mentaberre.

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Communicated by H. Kierdorf

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Mentaberre, G., Serrano, E., López-Olvera, JR. et al. Azaperone and sudden death of drive net-captured southern chamois. Eur J Wildl Res 58, 489–493 (2012). https://doi.org/10.1007/s10344-011-0564-4

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Keywords

  • Azaperone
  • Haloperidol
  • Fatigue
  • Mortality
  • Rupicapra pyrenaica