Multidimensional Gas Chromatography in Essential Oil Analysis. Part 1: Technical Developments

  • Leo Lebanov
  • Laura Tedone
  • Massoud Kaykhaii
  • Matthew R. Linford
  • Brett Paull
Part of the following topical collections:
  1. Rising Stars in Separation Science


Multidimensional gas chromatography (MDGC) is now established as a technique which can help resolve most of the co-elution problems presenting with conventional gas chromatography for highly complex samples. Essential oils (EOs) are often used in the optimisation and development of novel MDGC methods and related technologies, to demonstrate and assess performance. In this review, recent trends and technical developments in the optimisation of MDGC, modulation and system configuration, pertinent and applied to EO analysis, will be critically discussed. Optimisation of MDGC will be discussed with reference to different column configurations, modulation periods and detection. Attention is given to novel modulation systems, development of multiplex MDGC systems and new approaches which combine heart-cut and comprehensive modes within one system. A section of this review will be dedicated to the preparative application of the MDGC and its application in the isolation of less abundant compounds from complex EO matrices.


Multidimensional gas chromatography Essential oil Heart-cut multidimensional gas chromatography Comprehensive multidimensional gas chromatography Enantioselective multidimensional gas chromatography Optimisation Mass spectrometry Multiplex dual-column systems Preparative multidimensional gas chromatography 



Authors would like to thank University of Tasmania, Australia and Plant Therapy Inc., Twin Falls, Idaho, USA, for their generous provision of a jointly funded PhD scholarship and project support for Leo Lebanov.

Compliance with Ethical Standards

Conflict of interest

Authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.


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© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Australian Centre for Research on Separation Science (ACROSS), School of Natural SciencesUniversity of TasmaniaHobartAustralia
  2. 2.Department of Chemistry, Faculty of SciencesUniversity of Sistan and Baluchestan, University BoulevardZahedanIran
  3. 3.Department of Chemistry and BiochemistryBrigham Young UniversityProvoUSA

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