Abstract
Magnetic molecularly imprinted polymers (MMIPs) have attracted considerable attention in recent years as multifunctional materials suitable for use in the separation and purification fields. When modified with a specific functional polymer, MMIPs can be used to extract chemicals from a matrix and concentrate them based on specific recognition features, enabling more convenient retrieval of analytes using an external magnetic field. This review covers the preparation, characterization, and applications of various MMIPs, with particular focus on the technique used to coat such MMIPs with functional groups. A comprehensive overview of the applications of MMIPs to electrochemistry, food, and environmental analysis, and medicine is also presented. Furthermore, the problems and trends associated with MMIP-based applications are discussed.
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Kong J, Wang Y, Nie C, Ran D, Jia XP (2012) Anal Methods 4:1005–1011
He Y, Huang Y, Jin Y, Liu XJ, Liu GQ, Zhao R (2014) ACS Appl Mater Interfaces 6:9634–9642
Xu S, Guo C, Li Y, Yu ZR, Wei CH, Tang YW (2014) J Hazard Mater 264:34–41
Wang X, Li X, Luo C, Sun M, Li LL, Duan HM (2014) Electrochim Acta 130:519–525
Zheng HB, Mo JZ, Zhang Y, Gao Q, Ding J, Yu QW, Feng YQ (2014) J Chromatogr A 1329:17–23
Zhao M, Zhang C, Zhang Y, Guo XZ, Yan HS, Zhang HQ (2014) Chem Commun 50:2208–2210
Chen L, Li B (2012) Anal Methods 4:2613–2621
Yáñez-Sedeño P, Campuzano S, Pingarrón JM (2017) Anal Chim Acta 960:1–17
Wang XN, Liang RP, Meng XY, Qiu JD (2014) J Chromatogr A 1362:301–308
Urraca JL, Huertas-Pérez JF, Cazorla GA, Mora JG, García-Campaña AM, Moreno-Bondil MC (2016) Anal Bioanal Chem 408:3033–3042
Liu Y, Jia L (2008) Microchem J 89:72–76
Liu Y, Li H, Lin JM (2009) Talanta 77:1037–1042
Zhang Y, Liu R, Hu Y, Li GK (2009) Anal Chem 81:967–976
Parisi OI, Morellic C, Puoci F, Saturnino C, Caruso A, Sisci D, Trombino GE, Picci N, Sinicropi MS (2014) J Mater Chem B 2(38):6619–6625
Villar-Navarro M, Martín-Valero MJ, Fernández-Torres RM, Callejón-Mochón M, Ángel Bello-López M (2017) J Chromatogr B 1040:63–69
Lu S, Cheng G, Pang X (2003) J Appl Polym Sci 89:3790–3796
Lerma-García MJ, Zougagh M, Ríos A (2013) Microchim Acta 180:363–370
Yao GH, Liang RP, Huang CF, Wang Y, Qiu JD (2013) Anal Chem 85:11944–11951
Bedwell TS, Whitcombe M (2016) J Anal Bioanal Chem 408:1735–1751
Xiao D, Wang C, Dai H, Peng J, He J, Zhang K, Kong SM, Qiu PZ, He H (2015) Mol Recognit 28:277–284
Karimi MA, Ranjbar M, Behzadi Z (2017) Inorg Nano-Met Chem 47:308–312
Lin Z, Zhang H, Peng A, Lin Y, Li L, Huang Z (2016) Food Chem 200:32–37
Wang H, Liu Y, Wei S, Yao S, Zhang J, Huang H (2016) Anal Bioanal Chem 408:589–598
Liu X, Zhu L, Gao X (2016) Food Chem 202:309–315
Xie X, Chen L, Pan X, Wang SC (2015) J Chromatogr A 1405:32–39
Chen J, Liang RP, Wang XN, Qiu JD (2015) J Chromatogr A 1409:268–276
Zhou Y, Zhou T, Jin H, Jing T, Song B, Zhou YKS, Mei R, Lee YI (2015) Talanta 137:1–10
Huang Z, Lee HK (2015) J Chromatogr A 1414:41–50
Gao R, Zhang L, Hao Y, Cui XH, Liu DH, Zhang M, Tang YH (2015) J Sep Sci 38:3568–3574
Men HF, Liu HQ, Zhang ZL, Huang J, Zhang J, Zhai YY, Li L (2012) Environ Sci Pollut R 19:2271–2280
Ma RT, Shi YP (2015) Talanta 134:650–656
Wang S, Wang R, Wu X, Wang Y, Xue C, Wu JH, Hong JL, Liu J, Zhou XM (2012) J Chromatogr B 905:105–112
Ma G, Chen L (2014) J Chromatogr A 1329:1–9
Liu R, Guo Y, Odusote G, Qu FL, Priestley RD (2013) ACS Appl Mater Interfaces 5:9167–9171
Zhang Y, Li Y, Hu Y, Chen YQ (2010) J Chromatogr A 1217:7337–7344
Behbahani M, Bagheri S, Amini MM, Abandansari HS, Moazami HR, Bagheri A (2014) J Sep Sci 37:1610–1616
Li H, Hu X, Zhang Y, Shi SY, Jiang XY, Chen XQ (2015) J Chromatogr A 1404:21–27
Luo Y, Lu Z, Jiang Y, Wang DD, Yang LL, Huo PW, Da ZL, Bai XL, Xie XL, Yang PY (2014) Chem Eng J 240:244–252
Ming W, Wang X, Lu W, Zhang Z, Song X, Li J, Chen L (2017) Sens Actuator B Chem 238:1309–1315
Gao R, Kong X, Wang X, He X, Chen L, Zhang Y (2011) J Mater Chem 21:17863–17871
Jia X, Xu M, Wang Y, Ran D, Yang S, Zhang M (2013) Analyst 138:651–658
Jing T, Du H, Dai Q, Xia H, Niu J, Hao Q, Mei S, Zhou Y (2010) Biosens Bioelectron 26:301–306
Yang R, Liu Y, Yan X, Liu SM, Zheng HS (2016) J Mater Chem A 4:9807–9815
Heidari H, Razmi H, Jouyban A (2012) J Chromatogr A 1245:1–7
Pan SD, Chen XH, Li XP, Cai MQ, Shen HY, Zhao YG, Jin MC (2015) J Chromatogr A 1422:1–12
Giakisikli G, Anthemidis AN (2013) Anal Chim Acta 789:1–16
Gonzato C, Courty M, Pasetto P, Haupt K (2011) Adv Funct Mater 21:3947–3953
Xie L, Jiang R, Zhu F, Liu H, Ouyang GH (2014) Anal Bioanal Chem 406:377–399
Tavengwa NT, Cukrowska E, Chimuka L (2017) Sep Sci Technol 52:467–475
Li L, He X, Chen L, Zhang YK (2009) Chem Asian J 4:286–293
Kong X, Gao R, He X, Chen LX, Zhang YK (2012) J Chromatogr A 1245:8–16
Ebrahimzadeh H, Abedi H, Yamini Y, Adlnasab L (2010) J Sep Sci 33:3759–3766
Chen FF, Xie XY, Shi YP (2013) J Chromatogr A 1300:112–118
Bojdi MK, Behbahani M, Hesam G, Mashhadizadeh MH (2016) RSC Adv 6:32374–32380
Wang A, Lu H, Xu S (2016) J Agric Food Chem 64(24):5110–5116
Parisi OI, Morelli C, Puoci F, Saturnino C, Caruso A, Sisci D, Trombino GE, Picci N, Sinicropi MS (2014) J Mater Chem B 2:6619–6625
Aissa AB, Herrera-Chacon A, Pupin RR, Sotomayor MDPT, Pividori MI (2017) Biosens Bioelectron 88:101–108
Lahcen AA, Baleg AA, Baker P, Iwuoha E, Amine A (2017) Sens Actuator B Chem 241:698–705
Wu X, Li Y, Zhu X, He C, Wang Q, Liu S (2017) Talanta 162:57–64
Wierucka M, Biziuk M (2014) TrAC Trend Anal Chem 59:50–58
He D, Zhang X, Gao B, Wang L, Zhao Q, Chen H, Wang H, Zhao C (2014) Food Control 36:36–41
Shi S, Guo J, You Q, Chen X, Zhang Y (2014) Chem Eng J 243:485–493
Xu X, Duhoranimana E, Zhang X (2017) Talanta 163:31–38
Su X, Li X, Li J, Liu M, Lei F, Tan X, Li P, Luo W (2015) Food Chem 171:292–297
Xiao D, Dramou P, Xiong N, He H, Yuan D, Dai H, Li H, Ha X, Peng J, Li N (2013) Analyst 138:3287–3296
Ning F, Peng H, Li J, Chen L, Xiong H (2014) J Agric Food Chem 62:7436–7443
Sun B, Ni X, Cao Y, Cao G (2016) Biosens Bioelectron 78:7–13
Jiang H, Jiang D, Shao J, Sun X (2016) Biosens Bioelectron 75:411–419
Luo X, Luo S, Zhan Y, Shu H, Huang Y, Tu X (2011) J Hazard Mater 192:949–955
Pan J, Yao H, Xu L, Ou H, Huo P, Li X, Yan Y (2011) J Phys Chem C 115:5440–5449
Zhao X, Shi Y, Cai Y, Mou S (2008) Environ Sci Technol 42:1201–1206
Bagheri H, Roostaie A, Baktash MY (2014) Anal Chim Acta 816:1–7
Hu Y, Li Y, Liu R, Tan W, Li G (2011) Talanta 84(2):462–470
Zhou J, Gan N, Li T, Hu F, Li X, Wang L, Zheng L (2014) Biosens Bioelectron 54:199–206
Hemmati K, Sahraei R, Ghaemy M (2016) Polymer 101:257–268
Wang P, Zhao X, Luo J, Shang Y, Ye C, Guo S (2017) J Iran Chem Soc 14:755–762
Li X, Zhang B, Li W, Lei X, Fan X, Tian L, Zhang H, Zhang Q (2014) Biosens Bioelectron 51:261–267
Acknowledgements
This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2015R1A4A1042434).
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Li, G., Row, K.H. Applications of Magnetic Molecularly Imprinted Polymers (MMIPs) in the Separation and Purification Fields. Chromatographia 81, 73–88 (2018). https://doi.org/10.1007/s10337-017-3407-y
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DOI: https://doi.org/10.1007/s10337-017-3407-y

