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Exploration of Mesoporous Stationary Phases Prepared Using Deep Eutectic Solvents Combining Choline Chloride with 1,2-Butanediol or Glycerol for Use in Size-Exclusion Chromatography

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Abstract

Mesoporous siliceous particles were prepared using deep eutectic solvents (DESs)—either choline chloride and 1,2-butanediol in a 1:2 molar ratio (ChCl-B) or choline chloride and glycerol in a 1:2 molar ratio (ChCl-G)—and then tested as column packing materials in size-exclusion chromatography (SEC). When they were tested as column packing materials in SEC of a mixture of two dextrans with different molecular weights using a methanol mobile phase, the ChCl-G-based particles were not able to separate the dextrans, whereas the ChCl-B-based particles provided good separation (considerably better than that afforded by traditional sorbents) at a flow rate of 0.3 mL min−1. This high separating power of the ChCl-B-based particles can be attributed to the utilization of the DES ChCl-B during their preparation.

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References

  1. Yan H, Liu S, Gao M, Sun N (2013) Ionic liquids modified dummy molecularly imprinted microspheres as solid phase extraction materials for the determination of clenbuterol and clorprenaline in urine. J Chromatogr A 1294:10–16

    Article  CAS  Google Scholar 

  2. Gutiérrez MC, Ferrer ML, Yuste L, Rojo F, del Monte F (2010) Bacteria incorporation in deep-eutectic solvents through freeze-drying. Angew Chem Int Ed 49:2158–2162

    Article  Google Scholar 

  3. Xu L, Basheer C, Lee HK (2007) Developments in single-drop microextraction. J Chromatogr A 1152:184–192

  4. Mora-Pale M, Meli L, Doherty TV, Linhardt RJ, Dordick JS (2011) Room temperature ionic liquids as emerging solvents for the pretreatment of lignocellulosic biomass. Biotechnol Bioeng 108:1229–1245

    Article  CAS  Google Scholar 

  5. Abbott AP, Boothby D, Capper G, Davies DL, Rasheed RK (2004) Deep eutectic solvents formed between choline chloride and carboxylic acids: versatile alternatives to ionic liquids. J Am Chem Soc 126:9142–9147

  6. Hong EJ, Na KJ, Choi IG, Choi KC, Jeung EB (2004) Antibacterial and antifungal effects of essential oils from coniferous trees. Biol Pharm Bull 27:863–866

    Article  CAS  Google Scholar 

  7. Tankeviciute A, Kazlauskas R, Vickackaite V (2001) Headspace extraction of alcohols into a single drop. Analyst 126:1674–1677

    Article  CAS  Google Scholar 

  8. Choi YH, Spronsen J, Dai Y, Verberne M, Hollmann F, Arends IW (2011) Are natural deep eutectic solvents the missing link in understanding cellular metabolism and physiology. Plant Physiol 156:1701–1705

    Article  CAS  Google Scholar 

  9. Zhang QH, Vigier KDO, Royer S, Jerome F (2012) Deep eutectic solvents: syntheses, properties and applications. Chem Soc Rev 41:7108–7146

    Article  CAS  Google Scholar 

  10. Yan X, Yang C, Ren C, Li D (2008) Importance of extracting solvent vapor pressure in headspace liquid-phase microextraction. J Chromatogr A 1205:182–185

    Article  CAS  Google Scholar 

  11. Chen S, Zhang J, Wu T, Feng P, Bu X (2009) Multiroute synthesis of porous anionic frameworks and size-tunable extraframework organic cation-controlled gas sorption properties. J Am Chem Soc 131:16027–16029

    Article  CAS  Google Scholar 

  12. Chen S, Zhang J, Wu T, Feng P, Bu X (2010) Zinc(II)-boron(III)-imidazolate framework (ZBIF) with unusual pentagonal channels prepared from deep eutectic solvent. Dalton Trans 39:697–699

    Article  CAS  Google Scholar 

  13. Smith WL (1977) Selective solubility: “like dissolves like”. J Chem Educ 54:228–229

    Article  CAS  Google Scholar 

  14. Yan H, Sun N, Han Y, Yang C, Wang M, Wu R (2013) Ionic liquid-mediated molecularly imprinted solid-phase extraction coupled with gas chromatography-electron capture detector for rapid screening of dicofol in vegetables. J Chromatogr A 1307:21–26

    Article  CAS  Google Scholar 

  15. Theis AL, Waldack AJ, Hansen SM, Jeannot MA (2001) Head-space solvent microextraction. Anal Chem 73:5651–5654

    Article  CAS  Google Scholar 

  16. Okasaka M, Takaishi Y, Kashiwada Y, Kodzhimatov O, Ashurmetov O, Lin AJ, Consentino LM, Lee KH (2006) Terpenoids from Juniperus polycarpus var. seravschanica. Phytochemistry 67:635–2640

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Acknowledgments

This study was supported by a National Research Foundation Korea (NRF) Grant funded by the Korean government (MSIP) (No. NRF-2014R1A2A2A05002046).

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Authors and Affiliations

  1. Department of Chemistry and Chemical Engineering, Inha University, Incheon, 402-751, Republic of Korea

    Xiaoxia Li & Kyung Ho Row

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  1. Xiaoxia Li
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  2. Kyung Ho Row
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Correspondence to Kyung Ho Row.

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Li, X., Row, K.H. Exploration of Mesoporous Stationary Phases Prepared Using Deep Eutectic Solvents Combining Choline Chloride with 1,2-Butanediol or Glycerol for Use in Size-Exclusion Chromatography. Chromatographia 78, 1321–1325 (2015). https://doi.org/10.1007/s10337-015-2957-0

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  • DOI: https://doi.org/10.1007/s10337-015-2957-0

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