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Chromatographia

, Volume 78, Issue 19–20, pp 1245–1250 | Cite as

Validated Stability-Indicating Method for Alendronate Sodium Employing Zwitterionic Hydrophilic Interaction Chromatography Coupled with Charged Aerosol Detection

  • Surapuraju Pavan Kumar Raju
  • Mallikarjun Narayanam
  • Banothu Kranthi Kumar
  • Sreeram Tejaswee
  • Saranjit SinghEmail author
Original

Abstract

Alendronate sodium is widely used in the treatment of osteoporosis and Paget’s disease. The HPLC method development for alendronate sodium, in particular, is challenging owing to the absence of chromophoric group and its high polarity. In the present study, a short and simple isocratic method was developed involving hydrophilic interaction liquid chromatography, coupled with a charged aerosol detector. The developed method was validated according to the ICH Q2(R1) guideline and was successfully applied for the analysis of a marketed formulation containing the drug.

Keywords

CAD HILIC Alendronate sodium 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Surapuraju Pavan Kumar Raju
    • 1
  • Mallikarjun Narayanam
    • 1
  • Banothu Kranthi Kumar
    • 1
  • Sreeram Tejaswee
    • 1
  • Saranjit Singh
    • 1
    Email author
  1. 1.Department of Pharmaceutical AnalysisNational Institute of Pharmaceutical Education and Research (NIPER)MohaliIndia

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