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Analytical Challenges and Potential Applications of Sex Steroid Hormone Analysis in Breast and Prostate Cancer Patients

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Abstract

Advances in quantitative mass spectrometry technology have paved the way for routine use in clinical laboratories. One application is steroid analysis for investigation of gonadal and adrenal diseases. In oncology, routine use of steroid analysis is primarily restricted to testosterone analysis for addressing the castration level in androgen deprivation therapy and estradiol measurement to support determination of menopausal status. The increasing analytical performance of liquid chromatography–mass spectrometry (LC–MS)-based quantitative steroid analysis, opens opportunities for investigating new clinical applications. One of these is monitoring hormonal therapy in breast and prostate cancer patients. Several (pre-)analytical issues should be addressed when developing LC–MS-based steroid assays for these purposes. Assays that comprise multiple steroids provide an interesting approach to efficiently investigate a large variety of potential candidates.

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Author information

Authors and Affiliations

  1. Laboratory of Clinical Chemistry and Hematology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands

    Huub H. van Rossum

  2. Internal Medicine, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands

    Andries M. Bergman

  3. Laboratory of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands

    Eef Lentjes

Authors
  1. Huub H. van Rossum
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  2. Andries M. Bergman
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  3. Eef Lentjes
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Corresponding author

Correspondence to Huub H. van Rossum.

Additional information

Published in the topical collection Recent Developments in Clinical Omics with guest editors Martin Giera and Manfred Wuhrer.

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van Rossum, H.H., Bergman, A.M. & Lentjes, E. Analytical Challenges and Potential Applications of Sex Steroid Hormone Analysis in Breast and Prostate Cancer Patients. Chromatographia 78, 359–365 (2015). https://doi.org/10.1007/s10337-014-2797-3

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  • DOI: https://doi.org/10.1007/s10337-014-2797-3

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