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Chromatography-Based Determination of Anabolic Steroids in Biological Fluids: Future Prospects Using Electrochemistry and Miniaturized Microchip Device

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Abstract

Anabolic steroids form one of the important classes of doping agents and their consumption has been found to give benefits to the athletes. Inspite of the fact that they also produce adverse effects and damage several organs and systems, their consumption is continuously increasing in competitive games. The World Anti-Doping Agency and International Olympic Committee have banned the use of anabolic steroids and several other compounds. This article focuses an over view of various chromatographic techniques commonly used for detecting anabolic steroids and their metabolites during last 3 years in human biological fluids to establish the cases of doping. The possibility of electrochemistry- and microchip-based techniques have been considered as possible techniques for future to achieve simple and fast analysis at the site of competitive games as the first tool to detect the cases of doping.

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Acknowledgments

One of the authors is (RNG) is thankful to the Council of Scientific and Industrial Research, New Delhi and Department of Science and Technology, New Delhi for funding projects related to the analysis of doping agents. Thanks are also due to the Korean Federation of Science and Technology, South Korea for awarding Brain Pool Fellowship to RNG and IIT Roorkee, Roorkee (India) for sanctioning sabbatical leave.This research was also supported by the National Research Foundation funded by MEST of S. Korea (grant number: 20100029128)

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Authors and Affiliations

  1. Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, 247667, India

    Saurabh K. Yadav & Rajendra N. Goyal

  2. Department of Chemistry and Institute of BioPhysio Sensor Technology, Pusan National University, Busan, 609-735, South Korea

    Pranjal Chandra, Rajendra N. Goyal & Yoon-Bo Shim

Authors
  1. Saurabh K. Yadav
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  2. Pranjal Chandra
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  3. Rajendra N. Goyal
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  4. Yoon-Bo Shim
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Corresponding authors

Correspondence to Rajendra N. Goyal or Yoon-Bo Shim.

Additional information

Published in the topical collection New Developments for the Sensitive and Validated Drug Analysis Using Chromatographic Methods with guest editor Sibel A. Ozkan.

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Yadav, S.K., Chandra, P., Goyal, R.N. et al. Chromatography-Based Determination of Anabolic Steroids in Biological Fluids: Future Prospects Using Electrochemistry and Miniaturized Microchip Device. Chromatographia 76, 1439–1448 (2013). https://doi.org/10.1007/s10337-012-2351-0

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