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Factorial-Based Designs in Liquid Chromatography

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Abstract

In this paper, the review on application of factorial-based designs in liquid chromatography (LC) is given. The most useful and applicable full factorial design and reduced forms of full factorial design (fractional factorial design and Plackett–Burman design) applied in LC are presented. Literature survey shows that experimental design presents very often used tool in screening, optimization and robustness testing of LC methods.

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Acknowledgments

The authors thank the Ministry of Education and Science of the Republic of Serbia for supporting these investigations through the Project 172052.

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  1. Department of Drug Analysis, University of Belgrade, Vojvode Stepe 450, Belgrade, Serbia

    Biljana Jančić Stojanović

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  1. Biljana Jančić Stojanović
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Correspondence to Biljana Jančić Stojanović.

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Published in the topical collection Chemometrics in Chromatography with guest editors B. Jančić Stojanović and Y. Dotsikas.

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Jančić Stojanović, B. Factorial-Based Designs in Liquid Chromatography. Chromatographia 76, 227–240 (2013). https://doi.org/10.1007/s10337-012-2350-1

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