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Enantioseparation of the New Antifungal Drug Iodiconazole and Structurally Related Triadimenol Analogues by CE with Neutral Cyclodextrin Additives

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Abstract

Chiral separation of iodiconazole, a new antifungal drug, and 12 new structurally related triadimenol analogues were studied by capillary electrophoresis with seven neutral cyclodextrins. It was found that hydroxypropyl-γ-cyclodextrin (HP-γ-CD) was the most effective chiral selector. Furthermore, the influence of the concentration of HP-γ-CD, buffer pH, buffer concentration, temperature, and applied voltage was investigated, and the method was validated. The study of the analyte structure-enantioseparation relationships showed that substitutions in the side chains had important influences on enantiomeric separation.

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Acknowledgment

The authors would like to thank Prof. Zhang Wannian, Sun Qingyan, and Zhang Dazhi for kindly providing the triadimenol derivatives. This work was supported by a grant from the National Natural Science Foundation of China (no. 81072614) and a grant from the Doctoral Innovation Foundation of Second Military Medical University, China.

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Authors and Affiliations

  1. School of Pharmacy, Second Military Medical University, Shanghai, 200433, China

    Wuhong Li, Guangguo Tan, Chunquan Sheng, Xinrong Zhang, Zhenyu Zhu & Yifeng Chai

  2. Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200433, China

    Liang Zhao & Guoqing Zhang

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  1. Wuhong Li
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  2. Liang Zhao
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  3. Guangguo Tan
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  4. Chunquan Sheng
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  5. Xinrong Zhang
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  7. Guoqing Zhang
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  8. Yifeng Chai
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Correspondence to Yifeng Chai.

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Li, W., Zhao, L., Tan, G. et al. Enantioseparation of the New Antifungal Drug Iodiconazole and Structurally Related Triadimenol Analogues by CE with Neutral Cyclodextrin Additives. Chromatographia 73, 1009–1014 (2011). https://doi.org/10.1007/s10337-010-1897-y

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  • DOI: https://doi.org/10.1007/s10337-010-1897-y

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