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Synthesis and evaluation of new magneto-fluorescent carbon dot based on manganese citrate for MRI imaging

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Abstract

Objective

Medical imaging techniques have widely revolutionized the diagnosis and treatment of various health conditions. Among these techniques, magnetic resonance imaging (MRI) has stood out as a noninvasive and versatile tool. Now, a breakthrough innovation called “manganese-carbon dots” is poised to enhance MRI imaging and provide physicians with even greater insight into the human body.

Materials and methods

In this study, one-pot hydrothermal method was used to fabricate magneto-fluorescent carbon quantum dots using manganese citrate, urea, and Mn2+. Manganese citrateAQ3 acted as a carbon source and contrast agent. TEM,XPS, FTIR, UV–Vis, fluorescent analysis confirmed the successful synthesis of magneto-fluorescent carbon quantum dots. The MTT assay was used to study its biocompatiblity, Finallay application of itscompound for mri imaging was investigated.

Results

Characterization Techniques confirmed the succesful synthesis of product. MTT assay showed no toxicity of this product on HEK-293 cells. In addition, it exhibited high r1 relaxivity (7.4 mM–1 S−1) suggesting excellent potential of magneto-fluorescent carbon quantum dots as MRI T1 contrast agent and enabling specific imaging.

Conclusion

Based on the results obtained, the synthesized carbon quantum dots could be used as fluorescence/MRI bimodal platform for in vivo imaging.

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Data availability statement

The data that support the findings of this study are available from the corresponding author, upon reasonable request.

References

  1. Louie A (2010) Multimodality imaging probes: design and challenges. Chem Rev 110:3146–3195

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  2. Lee D-E, Koo H, Sun I-C, Ryu JH, Kim K, Kwon IC (2012) Multifunctional nanoparticles for multimodal imaging and theragnosis. Chem Soc Rev 41:2656–2672

    Article  PubMed  CAS  Google Scholar 

  3. Han L, Xia J-M, Hai X, Shu Y, Chen X-W, Wang J-H (2017) Protein-stabilized gadolinium oxide-gold nanoclusters hybrid for multimodal imaging and drug delivery. ACS Appl Mater Interfaces 9:6941–6949

    Article  PubMed  CAS  Google Scholar 

  4. Sun Y, Zhu X, Peng J, Li F (2013) Core–shell lanthanide upconversion nanophosphors as four-modal probes for tumor angiogenesis imaging. ACS Nano 7:11290–11300

    Article  PubMed  CAS  Google Scholar 

  5. Najdian A, Amanlou M, Beiki D, Bitarafan-Rajabi A, Mirzaei M, Ardestani MS (2022) Amino-modified-silica-coated gadolinium-copper nanoclusters, conjugated to AS1411 aptamer and radiolabeled with technetium-99 m as a novel multimodal imaging agent. Bioorg Chem 125:105827

    Article  PubMed  CAS  Google Scholar 

  6. Kim J, Piao Y, Hyeon T (2009) Multifunctional nanostructured materials for multimodal imaging, and simultaneous imaging and therapy. Chem Soc Rev 38:372–390

    Article  PubMed  CAS  Google Scholar 

  7. Chi C, Du Y, Ye J, Kou D, Qiu J, Wang J, Tian J, Chen X (2014) Intraoperative imaging-guided cancer surgery: from current fluorescence molecular imaging methods to future multi-modality imaging technology. Theranostics 4:1072

    Article  PubMed  PubMed Central  Google Scholar 

  8. Hauser SB, Kockro RA, Actor B, Sarnthein J, Bernays R-L (2016) Combining 5-aminolevulinic acid fluorescence and intraoperative magnetic resonance imaging in glioblastoma surgery: a histology-based evaluation. Neurosurgery 78:475–483

    Article  PubMed  Google Scholar 

  9. Tuerhong M, Yang XU, Xue-Bo YIN (2017) Review on carbon dots and their applications. Chinese J Anal Chem 45:139–150

    Article  Google Scholar 

  10. Jorns M, Pappas D (2021) A review of fluorescent carbon dots, their synthesis, physical and chemical characteristics, and applications. Nanomater (Basel, Switzerland). https://doi.org/10.3390/nano11061448

  11. Wang J, Qiu J (2016) A review of carbon dots in biological applications. J Mater Sci 51:4728–4738

    Article  ADS  CAS  Google Scholar 

  12. Liu Y, Huang H, Cao W, Mao B, Liu Y, Kang Z (2020) Advances in carbon dots: from the perspective of traditional quantum dots. Mater Chem Front 4:1586–1613

    Article  CAS  Google Scholar 

  13. Kang Z, Lee S-T (2019) Carbon dots: advances in nanocarbon applications. Nanoscale 11:19214–19224

    Article  PubMed  CAS  Google Scholar 

  14. Wang B, Song H, Qu X, Chang J, Yang B, Lu S (2021) Carbon dots as a new class of nanomedicines: opportunities and challenges. Coord Chem Rev 442:214010

    Article  CAS  Google Scholar 

  15. Li S, Li L, Tu H, Zhang H, Silvester DS, Banks CE, Zou G, Hou H, Ji X (2021) The development of carbon dots: From the perspective of materials chemistry. Mater Today 51:188–207

    Article  CAS  Google Scholar 

  16. Ghoreishi SM, Najdian A, Yadegari S, Seyedhamzeh M, Etemadzade M, Mirzaei M, Hadadian S, Alikhani Z, Ardestani MS (2020) The Use of Carbon Quantum Dot as Alternative of Stannous Chloride Application in Radiopharmaceutical Kits. Contrast Media Mol Imag 2020:1–11

    Article  Google Scholar 

  17. Liu J, Li R, Yang B (2020) Carbon dots: A new type of carbon-based nanomaterial with wide applications. ACS Cent Sci 6:2179–2195

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  18. Liu ML, Bin CB, Li CM, Huang CZ (2019) Carbon dots: synthesis, formation mechanism, fluorescence origin and sensing applications. Green Chem 21:449–471

    Article  CAS  Google Scholar 

  19. Jia Q, Zhao Z, Liang K, Nan F, Li Y, Wang J, Ge J, Wang P (2020) Recent advances and prospects of carbon dots in cancer nanotheranostics. Mater Chem Front 4:449–471

    Article  CAS  Google Scholar 

  20. Li Z, Wang L, Li Y, Feng Y, Feng W (2019) Frontiers in carbon dots: design, properties and applications. Mater Chem Front 3:2571–2601

    Article  CAS  Google Scholar 

  21. Chung YJ, Kim J, Park CB (2020) Photonic carbon dots as an emerging nanoagent for biomedical and healthcare applications. ACS Nano 14:6470–6497

    Article  PubMed  CAS  Google Scholar 

  22. Li X, Fu Y, Zhao S, Xiao J, Lan M, Wang B, Zhang K, Song X, Zeng L (2022) Metal ions-doped carbon dots: Synthesis, properties, and applications. Chem Eng J 430:133101

    Article  CAS  Google Scholar 

  23. Liu Y, Zhi X, Hou W, Xia F, Zhang J, Li L, Hong Y, Yan H, Peng C, de la Fuentea JM (2018) Gd 3+-Ion-induced carbon-dots self-assembly aggregates loaded with a photosensitizer for enhanced fluorescence/MRI dual imaging and antitumor therapy. Nanoscale 10:19052–19063

    Article  PubMed  CAS  Google Scholar 

  24. Ji D-K, Reina G, Liang H, Zhang D, Guo S, Ballesteros B, Menard-Moyon C, Li J, Bianco A (2021) Gadolinium-incorporated carbon nanodots for T 1-weighted magnetic resonance imaging. ACS Appl Nano Mater 4:1467–1477

    Article  CAS  Google Scholar 

  25. Atabaev TS (2018) Doped carbon dots for sensing and bioimaging applications: a minireview. Nanomaterials 8:342

    Article  PubMed  PubMed Central  Google Scholar 

  26. Tiron A, Stan CS, Luta G, Uritu CM, Vacarean-Trandafir I-C, Stanciu GD, Coroaba A, Tiron CE (2021) Manganese-doped N-hydroxyphthalimide-derived carbon dots—theranostics applications in experimental breast cancer models. Pharmaceutics 13:1982

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  27. Han C, Xu H, Wang R, Wang K, Dai Y, Liu Q, Guo M, Li J, Xu K (2016) Synthesis of a multifunctional manganese(ii)–carbon dots hybrid and its application as an efficient magnetic-fluorescent imaging probe for ovarian cancer cell imaging. J Mater Chem B 4:5798–5802

    Article  PubMed  CAS  Google Scholar 

  28. Mintz KJ, Zhou Y, Leblanc RM (2019) Recent development of carbon quantum dots regarding their optical properties, photoluminescence mechanism, and core structure. Nanoscale 11:4634–4652

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  29. Zhu S, Meng Q, Wang L, Zhang J, Song Y, Jin H, Zhang K, Sun H, Wang H, Yang B (2013) Highly photoluminescent carbon dots for multicolor patterning, sensors, and bioimaging. Angew Chemie Int Ed 52:3953–3957

    Article  CAS  Google Scholar 

  30. Yue L, Li H, Liu Q, Guo D, Chen J, Sun Q, Xu Y, Wu F (2019) Manganese-doped carbon quantum dots for fluorometric and magnetic resonance (dual mode) bioimaging and biosensing. Microchim Acta 186:1–8

    Article  ADS  Google Scholar 

  31. Sun S, Zhao L, Wu D, Zhang H, Lian H, Zhao X, Wu A, Zeng L (2021) Manganese-doped carbon dots with redshifted orange emission for enhanced fluorescence and magnetic resonance imaging. ACS Appl Bio Mater 4:1969–1975

    Article  PubMed  CAS  Google Scholar 

  32. Dhenadhayalan N, Lin K-C, Suresh R, Ramamurthy P (2016) Unravelling the multiple emissive states in citric-acid-derived carbon dots. J Phys Chem C 120:1252–1261

    Article  CAS  Google Scholar 

  33. Chen N, Shao C, Qu Y, Li S, Gu W, Zheng T, Ye L, Yu C (2014) Folic acid-conjugated MnO nanoparticles as a T 1 contrast agent for magnetic resonance imaging of tiny brain gliomas. ACS Appl Mater Interfaces 6:19850–19857

    Article  PubMed  CAS  Google Scholar 

  34. Shin J, Anisur RM, Ko MK, Im GH, Lee JH, Lee IS (2009) Hollow manganese oxide nanoparticles as multifunctional agents for magnetic resonance imaging and drug delivery. Angew Chemie Int Ed 48:321–324

    Article  CAS  Google Scholar 

  35. Huang J, Xie J, Chen K, Bu L, Lee S, Cheng Z, Li X, Chen X (2010) HSA coated MnO nanoparticles with prominent MRI contrast for tumor imaging. Chem Commun 46:6684–6686

    Article  CAS  Google Scholar 

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Acknowledgements

This manuscript is prepared based on PhD thesis of first author at Rasht Branch, Islamic Azad University, Rasht, Iran.

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Authors and Affiliations

  1. Department of Chemistry, Islamic Azad University, Rasht Branch, Rasht, Iran

    Vahid Ali, Hassan Kefayati & Afshin Pourahmad

  2. Faculty of Pharmacy, Department of Radiopharmacy, Tehran University of Medical Sciences, Tehran, Iran

    Mehdi Shafiee Ardestani

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  1. Vahid Ali
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  2. Hassan Kefayati
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  3. Mehdi Shafiee Ardestani
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  4. Afshin Pourahmad
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Correspondence to Hassan Kefayati.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee (Research Ethics Committees of School of Public Health & Allied Medical Sciences–Tehran University of Medical Sciences) and with the 1964 Helsinki declaration and its later amendments.

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Ali, V., Kefayati, H., Shafiee Ardestani, M. et al. Synthesis and evaluation of new magneto-fluorescent carbon dot based on manganese citrate for MRI imaging. Magn Reson Mater Phy 37, 139–148 (2024). https://doi.org/10.1007/s10334-023-01117-8

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