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Hyperpolarised 13C-MRI metabolic and functional imaging: an emerging renal MR diagnostic modality

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Abstract

Magnetic resonance imaging (MRI) is a well-established modality for assessing renal morphology and function, as well as changes that occur during disease. However, the significant metabolic changes associated with renal disease are more challenging to assess with MRI. Hyperpolarized carbon-13 MRI is an emerging technique which provides an opportunity to probe metabolic alterations at high sensitivity by providing an increase in the signal-to-noise ratio of 20,000-fold or more. This review will highlight the current status of hyperpolarised 13C-MRI and its translation into the clinic and how it compares to metabolic measurements provided by competing technologies such as positron emission tomography (PET).

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Funding

This study was funded by Aarhus University Research Foundation and Karen Elise Jensen Foundation.

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Authors and Affiliations

  1. Comparative Medicine Lab, Aarhus University, Aarhus, Denmark

    Michael Pedersen

  2. Department of Radiology, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK

    Stephan Ursprung & Ferdia Gallagher

  3. Department of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark

    Jens Dam Jensen & Bente Jespersen

  4. MR Research Centre, Department of Clinical Medicine, Aarhus University Hospital, Palle Juul Jensens Boulevard, 8200, Aarhus N, Denmark

    Christoffer Laustsen

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  1. Michael Pedersen
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  2. Stephan Ursprung
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Correspondence to Christoffer Laustsen.

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CL, SU, MP, BJ, JDJ, and FG declare no conflict of interest.

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Pedersen, M., Ursprung, S., Jensen, J.D. et al. Hyperpolarised 13C-MRI metabolic and functional imaging: an emerging renal MR diagnostic modality. Magn Reson Mater Phy 33, 23–32 (2020). https://doi.org/10.1007/s10334-019-00801-y

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