Skip to main content

Advertisement

SpringerLink
Log in

Intravascular signal suppression and microvascular signal mapping using delays alternating with nutation for tailored excitation (DANTE) pulse for arterial spin labeling perfusion imaging

  • Research Article
  • Published:
Magnetic Resonance Materials in Physics, Biology and Medicine Aims and scope Submit manuscript

Abstract

Objective

To optimize the delays alternating with nutation for tailored excitation (DANTE) pulse as a vascular crushing gradient to eliminate macro-and micro-vascular signals and to generate a macrovascular space-related map by applying DANTE with multiple conditions.

Materials and methods

Numerical simulation was performed to estimate the optimal flip angle (FA) of the DANTE. A phantom study was conducted to evaluate the impact of the FA and gradient area (GA) of the DANTE with three flow velocities and various parameters of the DANTE. Finally, an in vivo study was performed to assess the optimal DANTE parameters and to map the estimated macrovascular signal of the arterial spin labeling (ASL) signal.

Results

Numerical simulation revealed that the decrease of magnetization plateaued at 12.5° of FA. The phantom study showed that the setting of larger FA or GA decreased the ASL signals. The decrease of the ASL signal depended on the flow velocity, and the dependence increased with decreasing GA. The in vivo study revealed that larger FA and GA decreased the perfusion signal.

Discussion

An optimized DANTE makes it possible to efficiently suppress the macro-and-micro vascular signals depending on the flow velocity. Moreover, macrovascular signal mapping may be useful to assess altered hemodynamic states.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

References

  1. Williams DS, Detre JA, Leigh JS, Koretsky AP (1992) Magnetic resonance imaging of perfusion using spin inversion of arterial water. PNAS 89:212–216

    CAS  PubMed  Google Scholar 

  2. Detre JA, Leigh JS, Williams DS, Koretsky AP (1992) Perfusion imaging. Magn Reson Med 23:37–45

    CAS  PubMed  Google Scholar 

  3. Dai W, Garcia D, de Bazelaire C, Alsop DC (2008) Continuous flow-driven inversion for arterial spin labeling using pulsed radio frequency and gradient fields. Magn Reson Med 60:1488–1497

    PubMed  PubMed Central  Google Scholar 

  4. Chalela JA, Alsop DC, Gonzalez-Atavales JB, Maldjian JA, Kasner SE, Detre JA (2000) Magnetic resonance perfusion imaging in acute ischemic stroke using continuous arterial spin labeling. Stroke 31:680–687

    CAS  PubMed  Google Scholar 

  5. Weber MA, Zoubaa S, Schlieter M, Jüttler E, Huttner HB, Geletneky K, Ittrich C, Lichy MP, Kroll A, Debus J, Giesel FL, Hartmann M, Essig M (2006) Diagnostic performance of spectroscopic and perfusion MRI for distinction of brain tumors. Neurology 66:1899–1906

    CAS  PubMed  Google Scholar 

  6. Kimura H, Kado H, Koshimoto Y, Tsuchida T, Yonekura Y, Itoh H (2005) Multislice continuous arterial spin-labeled perfusion MRI in patients with chronic occlusive cerebrovascular disease: a correlative study with CO2 PET validation. J Magn Reson Imaging 22:189–198

    PubMed  Google Scholar 

  7. Ye FQ, Pekar JJ, Jezzard P, Duyn J, Frank JA, McLaughlin AC (1996) Perfusion imaging of the human brain at 1.5 T using a single-shot EPI spin tagging approach. Magn Reson Med 36:219–224

    Google Scholar 

  8. Amukotuwa SA, Yu C, Zaharchuk G (2015) 3D Pseudocontinuous arterial spin labeling in routine clinical practice: a review of clinically significant artifacts. J Magn Reson Imaging 43:11–27

    PubMed  Google Scholar 

  9. Ferré J-C, Bannier E, Raoult H, Mineur G, Carsin-Nicol B, Gauvrit J-Y (2013) Arterial spin labeling (ASL) perfusion: techniques and clinical use. Diagn Interv Imaging 94:1211–1223

    PubMed  Google Scholar 

  10. Watts JM, Whitlow CT, Maldjian JA (2013) Clinical applications of arterial spin labeling. NMR Biomed 26:892–900

    PubMed  Google Scholar 

  11. Alsop DC, Detre JA, Golay X, Günther M, Hendrikse J, Hernandez-Garcia L, Lu H, MacIntosh BJ, Parkes LM, Smits M, van Osch MJP, Wang DJJ, Wong EC, Zaharchuk G (2014) Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: a consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia. Magn Reson Med 73:102–116

    PubMed  PubMed Central  Google Scholar 

  12. Wang J, Yarnykh VL, Hatsukami T, Chu B, Balu N, Yuan C (2007) Improved suppression of plaque-mimicking artifacts in black-blood carotid atherosclerosis imaging using a multislice motion-sensitized driven-equilibrium (MSDE) turbo spin-echo (TSE) sequence. Magn Reson Med 58:973–981

    PubMed  Google Scholar 

  13. Matsuda T, Kimura H, Kabasawa H, Kanamoto M (2018) Three-dimensional arterial spin labeling imaging with a DANTE preparation pulse. Magn Reson Imaging 49:131–137

    CAS  PubMed  Google Scholar 

  14. Li L, Miller KL, Jezzard P (2012) DANTE-prepared pulse trains: a novel approach to motion-sensitized and motion-suppressed quantitative magnetic resonance imaging. Magn Reson Med 68:1423–1438

    PubMed  Google Scholar 

  15. Bouvy WH, Geurts LJ, Kuijf HJ, Luijten PR, Kappelle LJ, Biessels GJ, Zwanenburg JJM (2016) Assessment of blood flow velocity and pulsatility in cerebral perforating arteries with 7-T quantitative flow MRI. NMR Biomed 29:1295–1304

    CAS  PubMed  Google Scholar 

  16. Petersen ET, Lim T, Golay X (2006) Model-free arterial spin labeling quantification approach for perfusion MRI. Magn Reson Med 55:219–232

    PubMed  Google Scholar 

  17. Kamano H, Yoshiura T, Hiwatashi A, Abe K, Togao O, Yamashita K, Honda H (2013) Arterial spin labeling in patients with chronic cerebral artery steno-occlusive disease: correlation with 15O-PET. Acta Radiol 54:99–106

    PubMed  Google Scholar 

  18. Zhou J, Wilson DA, Ulatowski JA, Traystman RJ, van Zijl PC (2001) Two-compartment exchange model for perfusion quantification using arterial spin tagging. J Cereb Blood Flow Metab 21:440–455

    CAS  PubMed  Google Scholar 

  19. Fujiwara Y, Matsuda T, Kanamoto M, Tsuchida T, Tsuji K, Kosaka N, Adachi T, Kimura H (2016) Comparison of long-labeled pseudo-continuous arterial spin labeling (ASL) features between young and elderly adults: special reference to parameter selection. Acta Radiol 58:84–90

    PubMed  Google Scholar 

  20. Sorteberg W, Lindegaard KF, Rootwelt K, Dahl A, Russell D, Nyberg-Hansen R, Nornes H (1989) Blood velocity and regional blood flow in defined cerebral artery systems. Acta neurochir 97:47–52

    CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This work was supported in part by the Grants-in-Aid for Scientific Research (C) 18K07670 from the Japan Society for the Promotion of Science.

Author information

Authors and Affiliations

  1. Department of Medical Image Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

    Yasuhiro Fujiwara

  2. Department of Radiology, Faculty of Medical Sciences, University of Fukui, 23 Shimozaizuki, Eiheiji-Matsuoka, Yoshida-gun, Fukui, 910-1193, Japan

    Hirohiko Kimura & Nobuyuki Kosaka

  3. Radiological Center, University of Fukui Hospital, Fukui, Japan

    Shota Ishida, Masayuki Kanamoto & Toshiki Adachi

  4. Global MR Applications and Workflow, GE Healthcare Japan Corporation, Tokyo, Japan

    Naoyuki Takei

  5. Division of Ultra-high Field MRI, Institute for Biomedical Science, Iwate Medical University, Iwate, Japan

    Tsuyoshi Matsuda

Authors
  1. Yasuhiro Fujiwara
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hirohiko Kimura
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shota Ishida
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Masayuki Kanamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Naoyuki Takei
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Tsuyoshi Matsuda
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Nobuyuki Kosaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Toshiki Adachi
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

YF: study conception and design, acquisition of data, analysis and interpretation of data, drafting manuscript, critical revision. HK: study conception and design, critical revision. SI: study conception and design, acquisition of data, analysis and interpretation of data, critical revision. MK: study conception and design, acquisition of data, analysis and interpretation of data, critical revision. NT: study conception and design, acquisition of data, analysis and interpretation of data, critical revision. TM: study conception and design, acquisition of data, analysis and interpretation of data, critical revision. NK: analysis and interpretation of data, drafting manuscript, critical revision. TA: acquisition of data, analysis and interpretation of data, critical revision.

Corresponding author

Correspondence to Hirohiko Kimura.

Ethics declarations

Conflict of interest

Naoyuki Takei is an employee of GE Healthcare Japan Corporation.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee (institutional review board of the University of Fukui) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants for the in vivo study.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Fujiwara, Y., Kimura, H., Ishida, S. et al. Intravascular signal suppression and microvascular signal mapping using delays alternating with nutation for tailored excitation (DANTE) pulse for arterial spin labeling perfusion imaging. Magn Reson Mater Phy 33, 367–376 (2020). https://doi.org/10.1007/s10334-019-00785-9

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10334-019-00785-9

Keywords

Search

Navigation