Abstract
Objective
To investigate the sensitivity of modified Look–Locker inversion recovery (MOLLI) to measure changes in dissolved oxygen (DO) concentrations in water samples and to calculate sequence-specific relaxivity (r1m) and limit of detection (LOD).
Materials and methods
Ten water samples with a range of DO concentrations were scanned at 3 T using two variations of MOLLI schemes. Using linear regression the r1 of DO was estimated from the measured DO concentrations and T1 relaxation rates (R1). The results were combined with previously reported values on in vivo stability measures of the MOLLI sequences and used to estimate a LOD.
Results
DO concentrations ranged from 0.5 to 21.6 mg L−1. A linear correlation between DO and R1 was obtained with both MOLLI sequences, with an average correlation coefficient (R2) 0.9 and an average estimated r1 (\(\hat{r}_{1}\)) of 4.45 × 10−3 s−1 mg−1 L. Estimated LOD was ≈ 10 mg L−1.
Conclusion
MOLLI T1-mapping sequences may be used for detecting dissolved oxygen in vivo at 3 T with an \(\hat{r}_{1}\) in the range 4.18–4.8 × 10−3 s−1 mg−1 L and a corresponding LOD for dissolved oxygen of approximately 10 mg L−1. MOLLI-based T1 mapping may be a useful non-invasive tool for quantification of in vivo changes of DO concentration during oxygen challenges.
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Funding
This study is funded by the Norwegian Research Council, Grant Number 257454. Support with Winkler titration: Ingrid Moen.
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SASV: study conception and design, acquisition of data, analysis and interpretation of data, drafting of manuscript, critical revision. PKH, AB, CH, THS: study conception and design, drafting of manuscript, critical revision.
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Vatnehol, Haglerød and Amiry-Moghaddam are employee of Oxy Solutions A/S, a biotech company working with oxygenation of liquids. The authors declare that they have no conflict of interest.
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Vatnehol, S.A.S., Hol, P.K., Bjørnerud, A. et al. Determination of oxygen r1 at 3 Tesla using samples with a concentration range of dissolved oxygen. Magn Reson Mater Phy 33, 447–453 (2020). https://doi.org/10.1007/s10334-019-00783-x
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DOI: https://doi.org/10.1007/s10334-019-00783-x