Signal drop-off occurs in echo-planar imaging in inferior brain areas due to field gradients from susceptibility differences between air and tissue. Tailored-RF pulses based on a hyperbolic secant (HS) have been shown to partially recover signal at 3 T, but have not been tested at higher fields.
Materials and methods
The aim of this study was to compare the performance of an optimized tailored-RF gradient-echo echo-planar imaging (TRF GRE-EPI) sequence with standard GRE-EPI at 7 T, in a passive viewing of faces or objects fMRI paradigm in healthy subjects.
Increased temporal-SNR (tSNR) was observed in the middle and inferior temporal lobes and orbitofrontal cortex of all subjects scanned, but elsewhere tSNR decreased relative to the standard acquisition. In the TRF GRE-EPI, increased functional signal was observed in the fusiform, lateral occipital cortex, and occipital pole, regions known to be part of the visual pathway involved in face-object perception.
This work highlights the potential of TRF approaches at 7 T. Paired with a reversed-gradient distortion correction to compensate for in-plane susceptibility gradients, it provides an improved acquisition strategy for future neurocognitive studies at ultra-high field imaging in areas suffering from static magnetic field inhomogeneities.
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Ogawa S, Lee TM, Kay AR, Tank DW (1990) Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci USA 87:9868–9872
Mansfield P (1997) Multi-planar image formation using NMR spin echoes. J Phys C: Solid State Phys 10:L55–L58
Jezzard P, Clare S (1999) Sources of distortion in functional MRI data. Hum Brain Mapp 8(2–3):80–85
Jezzard P (2012) Correction of geometric distortion in fMRI data. NeuroImage 62:648–651
Ojemann JG, Akbudak E, Snyder AZ, McKinstry RC, Raichle ME, Conturo TE (1997) Anatomic localization and quantitative analysis of gradient refocused echo-planar fMRI susceptibility artifacts. NeuroImage 6:156–167
Jesmanowicz A, Biswal BB, Hyde JS (1999) Reduction in GR-EPI intravoxel dephasing using thin slices and short TE. In: Proceedings of the ISMRM scientific meeting, Philadelphia, p 1619
Bellgowan PS, Bandettini PA, van Gelderen P, Martin A, Bodurka J (2006) Improved BOLD detection in the medial temporal region using parallel imaging and voxel volume reduction. NeuroImage 29(4):1244–1251
Robinson SD, Pripfl J, Bauer H, Moser E (2008) The impact of EPI voxel size on SNR and BOLD sensitivity in the anterior medio-temporal lobe: a comparative group study of deactivation of the default mode. Magn Reson Mater Phy 21(4):279–290
Deichmann R, Gottfried JA, Hutton C, Turner R (2003) Optimized EPI for fMRI studies of the orbitofrontal cortex. NeuroImage 19(2):430–441
Frahm J, Klaus-Dietmar M, Wolfgang H (1995) The effects of intravoxel dephasing and incomplete slice refocusing on susceptibility contrast in gradient-echo MRI. J Magn Reson 109(2):234–237
Constable RT (1995) Functional MR imaging using gradient-echo echo-planar imaging in the presence of large static field inhomogeneities. J Magn Reson Imaging 5(6):746–752
Constable RT, Carpentier A, Pugh K, Westerveld M, Oszunar Y, Spencer DD (2000) Investigation of the human hippocampal formation using a randomized event-related paradigm and z-shimmed functional MRI. NeuroImage 12(1):55–62
Constable RT, Spencer DD (1999) Composite image formation in z-shimmed functional MR imaging. Magn Reson Med 42:110–117
Cordes D, Turski PA, Sorenson JA (2000) Compensation of susceptibility-induced signal loss in echo-planar imaging for functional applications. Magn Reson Imaging 18(9):1055–1068
Weiskopf N, Hutton C, Josephs O, Deichmann R (2006) Optimal EPI parameters for reduction of susceptibility-induced BOLD sensitivity losses: a whole-brain analysis at 3 T and 1.5 T. NeuroImage 33(2):493–504
Cho ZH, Ro YM (1992) Reduction of susceptibility artifact in gradient-echo imaging. Magn Reson Med 23:193–200
Chung JY, Yoon HW, Kim YB, Park HW, Cho ZH (2009) Susceptibility compensated fMRI study using a tailored RF echo planar imaging sequence. J Magn Reson Imaging 29(1):221–228
Wastling S, Barker GJ (2014) Designing hyperbolic secant excitation pulses to reduce signal dropout in gradient-echo echo-planar imaging. Mag Reson Med 74(3):661–672
Triantafyllou C, Hoge RD, Krueger G, Wiggins CJ, Potthast A, Wiggins GC, Wald LL (2005) Comparison of physiological noise at 1.5, 3 and 7 T and optimization of fMRI acquisition parameters. NeuroImage 26(1):243–250
van der Zwaag W, Francis S, Head K, Peters A, Gowland P, Morris P, Bowtell R (2009) fMRI at 1.5, 3 and 7 T: characterising BOLD signal changes. NeuroImage 47(4):1425–1434
Beisteiner R, Robinson S, Wurnig M, Hilbert M, Merksa K, Rath J et al (2011) Clinical fMRI: evidence for a 7 T benefit over 3T. NeuroImage 57(3):1015–1021
Rua C, Costagli M, Symms MR, Biagi L, Donatelli G, Cosottini M, Del Guerra A, Tosetti M (2017) Characterization of high-resolution gradient echo and spin echo EPI for fMRI in the human visual cortex at 7T. Magn Reson Imaging 40:98–108
Robitaille PM, Berliner L (2007) Ultra high field magnetic resonance imaging, vol 26. Springer US, New York
Farzaneh F, Riederer SJ, Pelc NJ (1990) Analysis of T2 limitations and off-resonance effects on spatial resolution and artifacts in echo-planar imaging. Magn Reson Med 14(1):123–139
Moser E, Stahlberg F, Ladd ME, Trattnig S (2012) 7-T MR—from research to clinical applications? NMR Biomed 25(5):695–716
Rua C, Wastling SJ, Costagli M, Biagi L, Symms MR, Del Guerra A, Cosottini M, Tosetti M, Barker GJ (2015) Demonstration of recovery of signal loss at 7T in gradient echo EPI using tailored-RF pulses. In: Proceedings of the ISMRM scientific meeting, Toronto, p 3917
De Renzi E, Perani D, Carlesimo GA, Silveri MC, Fazio F (1994) Prosopagnosia can be associated with damage confined to the right hemisphere—an MRI and PET study and a review of the literature. Neuropsychol 32:893–902
Puce A, Allison T, Asgari M, Gore JC, McCarthy G (1996) Differential sensitivity of human visual cortex to faces, letterings, and textures: a functional magnetic resonance imaging study. J Neurosci 16:5205–5215
Kanwisher N, McDermott J, Chun MM (1997) The Fusiform face area: a module in human extrastriate cortex specialized for face perception. J Neurosci 17(11):4302–4311
Haxby JV, Hoffman EA, Gobbini MI (2000) The distributed human neural system for face perception. Trends Neurosci 4(6):223–233
Rossion B, Caldara R, Seghier M, Schuller A-M, Lazeyras F, Mayer E (2003) A network of occipito-temporal face-sensitive areas besides the right middle fusiform gyrus is necessary for normal face processing. Brain 126:2381–2395
Pitcher D, Walsh V, Duchaine B (2011) The role of the occipital face area in the cortical face perception network. Exp Brain Res 209:481–493
Grill-Spector K, Kushnir T, Edelman S, Avidan G, Itzchak Y, Malach R (1999) Differential processing of objects under various viewing conditions in the human lateral occipital complex. Neuron 24(1):187–203
Grill-Spector K, Kanwisher N (2005) Visual Recognition: as soon as you know it is there, you know what it is. Psychol Sci 16(2):152–160
Kourtzi Z, Kanwisher N (2001) Representation of perceived object shape by the human lateral occipital complex. Science 293(5534):1506–1509
Wright P, Mougin O, Totman J, Peters A, Brookes M, Coxon R, Morris P, Clemence M, Francis S, Bowtell R, Gowland P (2008) Water proton T1 measurements in brain tissue at 7, 3, and 1.5 T using IR-EPI, IR-TSE, and MPRAGE: results and optimization. Magn Reson Mater Phy 21:121–130
Yacoub E, Duong TQ, De Moortele V, Lindquist M, Adriany G, Kim SG, Uğurbil K, Hu X (2003) Spin-echo fMRI in humans using high spatial resolutions and high magnetic fields. Magn Reson Med 49(4):655–664
Jenkinson M, Bannister P, Brady JM, Smith SM (2002) Improved optimisation for the Robust and accurate linear registration and motion correction of brain images. NeuroImage 17(2):825–841
Sergent J, Ohta S, Macdonald B (1992) Functional neuroanatomy of face and object processing—a positron emission tomography study. Brain 115:15–36
Gauthier I, Tarr MJ, Moylan J, Skudlarski P, Gore JC, Anderson AW (2000) The fusiform “face area” is part of a network that processes faces at the individual level. J Cogn Neurosci 12(3):495–504
Çukur T, Huth AG, Nishimoto S, Gallant JL (2013) Functional subdomains within FFA. J Neurosci 33:16748–16766
Rajimehr R, Young JC, Tootell RB (2009) An anterior temporal face patch in human cortex predicted my macaque maps. Proc Nat Acad Sci USA 106:1995–2000
Smith SM, Jenkinson M, Woolrich MW, Beckmann CF, Behrens TEJ, Johansen-Berg H, Gannister PR, De Luca M et al (2004) Advances in functional and structural MR image analysis and implementation as FSL. NeuroImage 23(S1):208–219
Worsley KJ (2001) Statistical analysis of activation images. In: Matthews PM, Smith SM, Jezzard P (eds) Functional MRI: an introduction to methods. Oxford University Press, Oxford, pp 251–270
Andersson JLR, Skare S, Ashburner J (2003) How to correct susceptibility distortions in spin-echo echo-planar images: application to diffusion tensor imaging. NeuroImage 20:870–888
Greve DN, Fischl B (2009) Accurate and robust brain image alignment using boundary-based registration. NeuroImage 48(1):63–72
Desikan RS, Ségonne F, Fischl B, Quinn BT, Dickerson BC, Blacker D, Buckner RL, Dale AM, Maguire RP, Human BT, Albert MS, Killiany RJ (2006) An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. NeuroImage 31:968–980
Kriegeskorte N, Formisano E, Sorger B, Goebel R (2007) Individual faces elicit distinct response patterns in human anterior temporal cortex. Proc Natl Acad Sci USA 104(51):20600–20605
Yang H, Susilo T, Duchaine B (2014) The anterior temporal face area contains invariant representations of face identity that can persist despite the loss of right FFA and OFA. Cereb Cortex 26(3):1096–1107
Nasr S, Tootell RBH (2012) Role of fusiform and anterior temporal cortical areas in facial recognition. NeuroImage 63(3):1743–1753
Uddin LQ, Kaplan JT, Molnar-Szakacs I, Zaidel E, Iacoboni M (2005) Self-face recognition activates a frontoparietal “mirror” network in the right hemisphere: an event-related fMRI study. NeuroImage 25:926–935
Robert Powell HW, Koepp MJ, Richardson MP, Symms MR, Thompson PJ, Duncan JS (2004) The application of functional MRI of memory in temporal lobe epilepsy: a clinical review. Epilepsia 45(7):855–863
Benke T, Köylü B, Visani P, Karner E, Brenneis C, Bartha L et al (2006) Language lateralization in temporal lobe epilepsy: a comparison between fMRI and the Wada Test. Epilepsia 47(8):1308–1319
Devlin JT, Russell RP, Davis MH, Price CJ, Wilson J, Moss HE, Matthews PM, Tyler LK (2000) Susceptibility induced loss of signal: comparing PET and fMRI on a semantic task. NeuroImage 11:589–600
Carr VA, Rissman J, Wagner AD (2010) Imaging the human medial temporal lobe with high-resolution fMRI. Neuron 65(3):298–308
Bonelli SB, Powell RH, Yogarajah M, Samson RS, Symms MR, Thompson PJ, Koepp MJ, Duncan JS (2010) Imaging memory in temporal lobe epilepsy: predicting the effects of temporal lobe resection. Brain 133(4):1186–1199
This work was supported by the Initial Training Network, HiMR, funded by the FP7 Marie Curie Actions of the European Commission (FP7-PEOPLE-2012-ITN-316716).
CR was supported by the Initial Training Network, HiMR, funded by the FP7 Marie Curie Actions of the European Commission (FP7-PEOPLE-2012-ITN-316716).
Conflict of interest
MRS is employed by General Electric Healthcare. GJB receives honoraria for teaching from General Electric Healthcare, who also part fund a PhD studentship. GJB acts as a consultant for IXICO.
All procedures involving human participants were in accordance with the ethical standards of the competent ethics committee and with the 1964 Helsinki declaration and its later amendments.
Written informed consent was obtained from all individual participants included in the study.
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Rua, C., Wastling, S.J., Costagli, M. et al. Improving fMRI in signal drop-out regions at 7 T by using tailored radio-frequency pulses: application to the ventral occipito-temporal cortex. Magn Reson Mater Phy 31, 257–267 (2018). https://doi.org/10.1007/s10334-017-0652-x
- Functional MRI
- Ultra high field
- Tailored radio-frequency pulse
- Signal drop-out recovery