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Highly-accelerated self-gated free-breathing 3D cardiac cine MRI: validation in assessment of left ventricular function

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Abstract

Objective

This work presents a highly-accelerated, self-gated, free-breathing 3D cardiac cine MRI method for cardiac function assessment.

Materials and methods

A golden-ratio profile based variable-density, pseudo-random, Cartesian undersampling scheme was implemented for continuous 3D data acquisition. Respiratory self-gating was achieved by deriving motion signal from the acquired MRI data. A multi-coil compressed sensing technique was employed to reconstruct 4D images (3D+time). 3D cardiac cine imaging with self-gating was compared to bellows gating and the clinical standard breath-held 2D cine imaging for evaluation of self-gating accuracy, image quality, and cardiac function in eight volunteers. Reproducibility of 3D imaging was assessed.

Results

Self-gated 3D imaging provided an image quality score of 3.4 ± 0.7 vs 4.0 ± 0 with the 2D method (p = 0.06). It determined left ventricular end-systolic volume as 42.4 ± 11.5 mL, end-diastolic volume as 111.1 ± 24.7 mL, and ejection fraction as 62.0 ± 3.1%, which were comparable to the 2D method, with bias ± 1.96 × SD of −0.8 ± 7.5 mL (p = 0.90), 2.6 ± 3.3 mL (p = 0.84) and 1.4 ± 6.4% (p = 0.45), respectively.

Conclusion

The proposed 3D cardiac cine imaging method enables reliable respiratory self-gating performance with good reproducibility, and provides comparable image quality and functional measurements to 2D imaging, suggesting that self-gated, free-breathing 3D cardiac cine MRI framework is promising for improved patient comfort and cardiac MRI scan efficiency.

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Acknowledgements

This work was supported in part by Grant from the NIH K25EB014914 (JL), NIH R56HL133663 (JL), GE Healthcare (JL), NIH R01NS059944 (DS), R01HL114118 (DS).

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Authors and Affiliations

  1. Department of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry St, Suite 350, San Francisco, CA, 94107, USA

    Jing Liu, Hsin-Wei Shen, Chengcheng Zhu, Yan Wang, Karen Ordovas & David Saloner

  2. Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, NY, USA

    Li Feng

  3. Department of Medicine, University of California San Francisco, San Francisco, CA, USA

    Kanae Mukai & Gabriel C. Brooks

  4. Radiology Service, VA Medical Center, San Francisco, CA, USA

    David Saloner

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  1. Jing Liu
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Correspondence to Jing Liu.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study was conducted under IRB approvals (#12-09781, #14-14769) at University of California San Francisco.

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Liu, J., Feng, L., Shen, HW. et al. Highly-accelerated self-gated free-breathing 3D cardiac cine MRI: validation in assessment of left ventricular function. Magn Reson Mater Phy 30, 337–346 (2017). https://doi.org/10.1007/s10334-017-0607-2

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