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In vivo MR spectroscopy of human breast tissue: quantification of fatty acid composition at a clinical field strength (3 T)

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Abstract

Objective

To evaluate the feasibility of in vivo measurement of the fatty acid (FA) composition of breast adipose tissue by MRS on a clinical platform.

Material and methods

MRS experiments were performed at 3 T, using a STEAM sequence, on 25 patients diagnosed with breast cancer. MR spectra, acquired on healthy breast tissue, were analysed with the LCModel.

Results

The measured values of the saturated fatty acid (SFA), mono-unsaturated fatty acid (MUFA) and poly-unsaturated fatty acid (PUFA) fractions were 23.8 ± 7.1 %, 55.4 ± 6.8 % and 20.8 ± 4.4 %, respectively. The values of SFA, MUFA and PUFA observed in the current study are in the same range as those found in two previous studies performed at 7 T.

Conclusion

The results of the current study show that it is possible to quantify the fatty acid composition of breast tissue in vivo in a clinical setting (3 T).

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Authors’ contribution

COUM A: Data analysis. OULDAMER L: Protocol/project development, data collection and management. NOURY F: Data analysis. BARANTIN L: Protocol/project development, data collection and management. SAINT-HILAIRE A: Protocol/project development. VILDE A: Protocol/project development. BOUGNOUX P: Protocol/project development. GAMBAROTA G: Protocol/project development.

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Authors and Affiliations

  1. Université de Rennes 1, 35000, Rennes, France

    Amandine Coum, Fanny Noury & Giulio Gambarota

  2. LTSI, INSERM, UMR 1099, 35000, Rennes, France

    Amandine Coum, Fanny Noury & Giulio Gambarota

  3. Département de Gynécologie, CHRU de Tours, 37044, Tours, France

    Lobna Ouldamer

  4. INSERM U1069, 37044, Tours, France

    Lobna Ouldamer & Philippe Bougnoux

  5. Université François-Rabelais, 37044, Tours, France

    Lobna Ouldamer, Laurent Barantin & Philippe Bougnoux

  6. INSERM U930, 37044, Tours, France

    Laurent Barantin

  7. Département de Radiologie, CHRU de Tours, 37044, Tours, France

    Aymeric Saint-Hilaire & Anne Vilde

  8. Département d’Oncologie, CHRU de Tours, 37044, Tours, France

    Philippe Bougnoux

Authors
  1. Amandine Coum
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  2. Lobna Ouldamer
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  3. Fanny Noury
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  4. Laurent Barantin
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  5. Aymeric Saint-Hilaire
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  6. Anne Vilde
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  7. Philippe Bougnoux
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  8. Giulio Gambarota
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Corresponding author

Correspondence to Amandine Coum.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Coum, A., Ouldamer, L., Noury, F. et al. In vivo MR spectroscopy of human breast tissue: quantification of fatty acid composition at a clinical field strength (3 T). Magn Reson Mater Phy 29, 1–4 (2016). https://doi.org/10.1007/s10334-015-0506-3

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  • DOI: https://doi.org/10.1007/s10334-015-0506-3

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