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Direct cerebral and cardiac 17O-MRI at 3 Tesla: initial results at natural abundance

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Abstract

Purpose

To establish direct 17O-magnetic resonance imaging (MRI) for metabolic imaging at a clinical field strength of 3 T.

Methods

An experimental setup including a surface coil and transmit/receive switch was constructed. Natural abundance in vivo brain images of a volunteer were acquired with a radial three-dimensional (3D) sequence in the visual cortex and in the heart with electrocardiogram (ECG)-gating.

Results

In the brain, a signal-to-noise ratio of 36 was found at a nominal resolution of (5.6 mm)3, and a transverse relaxation time of T2* = (1.9 ± 0.2) ms was obtained. In the heart 17O images were acquired with a temporal resolution of 200 ms.

Conclusion

Cerebral and cardiac 17O-MRI at natural abundance is feasible at 3 T.

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Acknowledgments

The authors thank Manuela Rösler and Reiner Umathum from the German Cancer Research Center (DKFZ) for help with the RxTx switch and the preamplifier, Waldemar Schimpf and Thomas Günter from the workshop at the neuro-center of the University Medical Center Freiburg for assistance with the construction of the setup, and Vladimir Jellus and Peter Speier from Siemens Healthcare for providing the basic UTE pulse sequence code.

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Authors and Affiliations

  1. German Cancer Consortium (DKTK), Heidelberg, Germany

    Robert Borowiak

  2. Department of Radiology, Medical Physics, University Medical Center Freiburg, Breisacher Str. 60a, 79106, Freiburg, Germany

    Robert Borowiak, Jens Groebner, Martin Haas, Jürgen Hennig & Michael Bock

  3. German Cancer Research Center (DKFZ), Heidelberg, Germany

    Robert Borowiak

Authors
  1. Robert Borowiak
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  2. Jens Groebner
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  3. Martin Haas
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  4. Jürgen Hennig
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  5. Michael Bock
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Correspondence to Robert Borowiak.

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Borowiak, R., Groebner, J., Haas, M. et al. Direct cerebral and cardiac 17O-MRI at 3 Tesla: initial results at natural abundance. Magn Reson Mater Phy 27, 95–99 (2014). https://doi.org/10.1007/s10334-013-0409-0

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  • DOI: https://doi.org/10.1007/s10334-013-0409-0

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