A battery-driven, low-field NMR unit for thermally and hyperpolarized samples

Abstract

Object

The design of a multinuclear low-field NMR unit with variable field strength <6 mT providing accurate spin manipulations and sufficient sensitivity for direct detection of samples in thermal equilibrium to aid parahydrogen-based hyperpolarization experiments.

Materials and methods

An optimized, resistive magnet connected to a battery or wall-power driven current source was constructed to provide a magnetic field <6 mT. A digital device connected to a saddle-shaped transmit- and solenoid receive-coil enabled MR signal excitation and detection with up to 106 samples/s, controlled by a flexible pulse-programming software.

Results

The magnetization of thermally polarized samples at 1.8 and 5.7 mT is detected in a single acquisition with a SNR ≈101 and ≈102 and a line width of 42 and 32 Hz, respectively. Nuclear spins are manipulated to an uncertainty of ±1° by means of pulses, which can be arranged in an arbitrary combination. As a demonstration, standard experiments for the measurement of relaxation parameters of thermally polarized samples were implemented. The detection of much stronger hyperpolarized signal was exemplified employing parahydrogen.

Conclusion

Direct detection of thermal and hyperpolarized 1H-MR signal in a single acquisition and accurate spin manipulations at 1.8 and 5.5 mT were successfully demonstrated.

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Abbreviations

ADC:

Analog to digital converter

DAC:

Digital to analog converter

l:

Length

SOT:

Spin-order transfer

PASADENA:

Parahydrogen and synthesis allows dramatically enhanced nuclear alignment

pH2 :

Parahydrogen

PHIP:

Parahydrogen induced hyperpolarization

SABRE:

Signal amplification by reversible exchange

T/R:

Transmit/receive

r:

Radius

I/O:

Input/Output

IR:

Inversion recovery

SR:

Saturation recovery

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Acknowledgments

Part of this work was supported by the Innovationsfonds Baden-Würtemberg and the Academy of Excellence of the German Research Foundation. The authors wish to thank D. I. Hoult for helpful discussions.

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Correspondence to Jan-Bernd Hövener.

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Borowiak, R., Schwaderlapp, N., Huethe, F. et al. A battery-driven, low-field NMR unit for thermally and hyperpolarized samples. Magn Reson Mater Phy 26, 491–499 (2013). https://doi.org/10.1007/s10334-013-0366-7

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Keywords

  • NMR
  • Low-field NMR
  • Hyperpolarization
  • Parahydrogen
  • SABRE
  • PASADENA
  • PHIP