Abstract
Vessel size index (VSI) measurements have been validated on rats bearing a glioma with high doses of contrast agent. The aim of this study was to evaluate the impact of using a reduced dose of contrast agent, necessary for clinical trials. Experiments were performed on rats at three doses of AMI-227 and clearly show higher VSI values at lower doses, whatever the region of interest (contralateral, peritumoral and intratumoral tissue). These results are in good correlation with Monte-Carlo simulations on healthy brain and suggest that only relative values can be obtained at clinical contrast agent doses and magnetic fields.
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Acknowledgments.
We thank Laboratoires Guerbet for kindly providing AMI-227. This work was supported by research grants from the Association pour la Recherche sur le Cancer, Comité de l’Isère de la Ligue contre le Cancer, programme interdisciplinaire CNRS–INSERM–CEA “Imagerie du Petit Animal” and Région Rhône-Alpes.
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Troprès, I., Lamalle, L., Farion, R. et al. Vessel size imaging using low intravascular contrast agent concentrations. MAGMA 17, 313–316 (2004). https://doi.org/10.1007/s10334-004-0067-3
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DOI: https://doi.org/10.1007/s10334-004-0067-3