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The Chinese-German Journal of Clinical Oncology

, Volume 12, Issue 12, pp 592–595 | Cite as

Clinical study of docetaxel combined with concurrent radiotherapy in patients with advanced nasopharyngeal carcinoma

  • Wei Luo
  • Wei GeEmail author
  • Yongfa Zheng
  • Xianfeng Pan
  • Jing Song
  • Huilin Xu
  • Pingpo Ming
Article
  • 34 Downloads

Abstract

Objective

The aim of this study was to study the short-term curative effects and adverse reactions of docetaxel (DOC) in concurrent chemoradiotherapy compared to DDP plus 5-Fu (DF) combined with concurrent radiotherapy in patients with advanced nasopharyngeal carcinoma.

Methods

Thirty-three patients in the experimental group (DOC group) were given DOC 25 mg/m2 ivgtt, d1, 7 times, concurrent radiotherapy was performed from d1. Thirty-three patients in the control group (DF group) were given cisplatin 25 mg/m2 ivgtt d1-3 and 5-Fu 550 mg/m2 iv, d1-5, 3 weeks a cycle, 2 cycles, and concurrent radiotherapy was performed from d1. Six MV X-ray and 9 MeV electronic line for external irradiation were adopted in concurrent radiotherapy.

Results

The response rates of DOC group and DF group were 90.9% and 93.9%, the rates of neutropenia were 45.45% and 67.74%, and the rates of oral mucositis were 60.61% and 90.32%.

Conclusion

The difference of short-term curative effects between DOC group and DF group was not statistically significant in patients with advanced nasopharyngeal carcinoma. The rates of adverse reactions were lower in DOC group. DOC combined with concurrent radiotherapy could be a new choice for patients with advanced nasopharyngeal carcinoma.

Key words

nasopharyngeal carcinoma docetaxel (DOC) concurrent radiotherapy 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Wei Luo
    • 1
  • Wei Ge
    • 1
    Email author
  • Yongfa Zheng
    • 1
  • Xianfeng Pan
    • 1
  • Jing Song
    • 1
  • Huilin Xu
    • 1
  • Pingpo Ming
    • 1
  1. 1.Cancer CenterRenmin Hospital of Wuhan UniversityWuhanChina

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