Abstract
Objective
The aim of the study was to detect the levels of mannose-binding lectin (MBL), MBL-associated serine protease 2 (MASP-2) and explore the clinical significances of them in patients with primary thyroid neoplasms.
Methods
By using ELISA method, we detected the serum levels of MBL and MASP-2 in 26 patients with papillary thyroid carcinoma (PTC), 30 patients with thyroid adenoma (TA) and 26 healthy people, respectively.
Results
Serum MBL level was (565.23 ± 76.70) μg/L in PTCs higher than (324.267 ± 24.74) μg/L in TAs, and (152.69 ± 16.95) μg/L in healthy of controlling group. There was statistical significance between PTC and TA (P < 0.05), however there was no difference between TA and healthy (P > 0.05). Serum MASP-2 level was (726.153 ± 78.88) μg/L in PTCs higher than (379.266 ± 30.26) μg/L in TAs, and (203.846 ± 29.09) μg/L in healthy. Serum MASP-2 level was higher in PTCs than TAs, and the difference had statistical significance (P < 0.01). But no difference was observed between in TAs and healthy.
Conclusion
These findings might reflect inflammatory processes induced by defense mechanisms, in response to the development of the tumour. MBL may also be involved in the elimination of possible tumourigenic pathogens.
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Supported by a grant of Natural Science Funds Projects of Hebei Province (No. C2008001306).
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Shi, Y., Liu, G., Zhang, H. et al. Expressions and clinical significances of mannose-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) in patients with thyroid neoplasm. Chin. -Ger. J. Clin. Oncol. 12, 106–108 (2013). https://doi.org/10.1007/s10330-012-1122-6
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DOI: https://doi.org/10.1007/s10330-012-1122-6