Skip to main content

Advertisement

SpringerLink
Log in

Extranodal natural killer/T-cell lymphoma, nasal type: epidemiology study

  • Published:
The Chinese-German Journal of Clinical Oncology

Abstract

Extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKTCL) is a rarely kind of non-Hodgkin lymphoma (NHL). It is much more frequent in Asian and Latin American countries than other part of the world. It typically affects nasal cavity. In China, one of its endemically places, ENKTCL accounts for 74%–96% of nasal NHL. Patients with ENKTCL usually show a highly aggressive clinical course, and its etiology is unclear. However, it is already proved that ENKTCL is associated with Epstein-Barr virus (EBV) infection, regardless patients’, ethnicity and areas. Some studies show that the risk will increase among several occupations, such as farmer, who are frequently exposure to pesticides and chemical solvent and risk can be cut down if taking some protective measures.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. McBride P. Photographs of a case of rapid destruction of the nose and face. 1897. J Laryngol Otol, 1991, 105: 1120.

    Article  PubMed  CAS  Google Scholar 

  2. Harris NL, Jaffe ES, Diebold J, et al. The World Health Organization classification of neoplastic diseases of the haematopoietic and lymphoid tissues: report of the Clinical Advisory Committee Meeting — Airlie House, Virginia, November 1977. J Clin Oncol, 1999, 1: 3835–3849.

    Google Scholar 

  3. Harris NL, Jaffe ES, Stein H, et al. A revised European-American classification of lymphoid neoplasms: A proposal from the International lymphoma Study Group. Blood, 1994, 5: 1361–1392.

    Google Scholar 

  4. AI-Hakeem DA, Fedele S, Carlos R, et, al. Extranodal NK/T-cell lymphoma, nasal type. Oral Oncol, 2007, 43: 4–14.

    Article  Google Scholar 

  5. Wang DB, Ming M, Liu JH, et al. The significance and features of apoptosis and proliferation of NK/T cell lymphoma. Chinese-German J Clin Oncol, 2011, 10: 286–289.

    Article  Google Scholar 

  6. Li YX, Coucke PA, Li JY, et al. Primary non-Hodgkin’s lymphoma of the nasal cavity: prognostic significance of paranasal extension and the role of radiotherapy and chemotherapy. Cancer, 1998, 83: 449–456.

    Article  PubMed  CAS  Google Scholar 

  7. Kim BS, Kim DW, Im SA, et al. Effective second-line chemotherapy for extranodal NK/T-cell lymphoma consisting of etoposide, ifosfamide, methotrexate, and prednisolone. Ann Oncol, 2009, 20: 121–128.

    Article  PubMed  Google Scholar 

  8. Zhang XX, Xie CH, Xu Y, et, al. Salvage treatment improved survival of patients with relapsed extranodal natural killer/t-cell lymphoma, nasal type. Int J Radiat Oncol Biol Phys, 2009, 74: 747–752.

    Article  PubMed  Google Scholar 

  9. Li YX, Coucke PA, Li JY, et al. Primary non-Hodgkin’s lymphoma of the nasal cavity: prognostic significance of paranasal extention and the role of radiotherapy and chemotherapy. Cancer, 1998, 83: 449–456.

    Article  PubMed  CAS  Google Scholar 

  10. Liang R, Todd D, Chan TK, et al. Treatment outcome and prognostic factors for primary nansal lymphoma. J Clin Oncol, 1995, 13: 666–670.

    PubMed  CAS  Google Scholar 

  11. Yu JB, Zuo Z, Tang Y, et al. Extranodal nasal-type natural killer/T-cell lymphoma of the skin: a clinicopathologic study of 16 cases in China. Hum Pathol, 2009, 40: 807–816.

    Article  PubMed  CAS  Google Scholar 

  12. Suzuki R, Takeuchi K, Ohshima K, et al. Extranodal NK/T-cell lymphoma: diagnosis and treatment cues. Hematol Oncol, 2008, 26: 66–72.

    Article  PubMed  Google Scholar 

  13. Rodriguez J, Romaguera JE, Manning J, et al. Nasal-type T/NK lymphomas: a clinicopathologic study of 13 cases. Leuk Lymphoma, 2000, 39: 139–144.

    Article  PubMed  CAS  Google Scholar 

  14. Quintanilla-Martinez L, Franklin JL, Guerrero I, et al. Histological and immunophenotypic profile of nasal NK/T cell lymphomas from Peru: high prevalence of p53 overexpression. Hum Pathol, 1999, 30: 849–855.

    Article  PubMed  CAS  Google Scholar 

  15. Xu JX, Hoshida Y, Yang WI, et al. Life-style and environmental factors in the development of nasal NK/T-cell lymphoma: a case-control study in East Asia. Int J Cancer, 2007, 120: 406–410.

    Article  PubMed  CAS  Google Scholar 

  16. Kojya S, Matsumura J, Ting L, et al. Familial nasal NK/T-cell lymphoma and pesticide use. Am J Hematol, 2001, 66: 145–147.

    Article  PubMed  CAS  Google Scholar 

  17. Zhang Y, Holford TR, Leaderer B, et al. Hair-coloring product use and risk of non-Hodgkin’s lymphoma: a population-based case-control study in Connecticut. Am J Epidemiol, 2004, 159: 148–154.

    Article  PubMed  Google Scholar 

  18. Harabuchi Y, Yamanaka N, Kataura A, et al. Epstein-Barr virus in nasal T-cell lymphomas in patients with lethal midline granuloma. Lancet, 1990, 335: 128–130.

    Article  PubMed  CAS  Google Scholar 

  19. Chan JKC, Quintanilla-Martinez L, Ferry JA, et al. “Extranodal NK/T-cell lymphoma, nasal type,” in WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. International Agency for Research on Cancer. 2008. 285–288.

  20. Hsieh PP, Tung CL, Chan AB, et al. EBV viral load in tumor tissue is an important prognostic indicator for nasal NK/T-cell lymphoma. Am J Clin Pathol, 2007, 128: 579–584.

    Article  PubMed  Google Scholar 

  21. Barrionuevo C, Zaharia M, Martinez MT et al. Extranodal NK/T-cell lymphoma, nasal type: study of clinicopathologic and prognosis factors in a series of 78 cases from Peru. Appl Immunohistochem Mol Morphol, 2007, 15: 38–44.

    Article  PubMed  Google Scholar 

  22. Borisch B, Henning I, Laeng RH, et al. Association of the subtype 2 of the Epstein-Barr virus with T-cell non-Hodgkin’s lymphoma of the midline granuloma type. Blood, 1993, 82: 858–864.

    PubMed  CAS  Google Scholar 

  23. Tomita Y, Ohsawa M, Qiu K, et al. Epstein-Barr virus in lymphoproliferative diseases in the sino-nasal region: close association with CD56+ immunophenotype and polymorphic reticulosis morphology. Int J Cancer, 1997, 70: 9–13.

    Article  PubMed  CAS  Google Scholar 

  24. Kim JE, Kim YA, Jeon YK, et al. Comparative analysis of NK/T-cell lymphoma and peripheral T-cell lymphoma in Korea: Clinicopathological correlations and analysis of EBV strain type and 30-bp deletion variant LMP1. Pathol Int, 2003, 53: 735–743.

    PubMed  CAS  Google Scholar 

  25. Tomita Y, Ohsawa M, Mishiro Y, et al. The presence and subtype of Epstein-Barr virus in B and T cell lymphomas of the sino-nasal region from the Osaka and Okinawa districts of Japan. Lab Invest, 1995, 73: 190–196.

    PubMed  CAS  Google Scholar 

  26. Hirakawa S, Kuyama M, Takahashi S, et al. Nasal and nasal-type natural killer/T-Cell lymphoma. J Am Acad Dermatol, 1999, 40: 268–272.

    Article  PubMed  CAS  Google Scholar 

  27. Kuo TT, Shih LY, Tsang NM, et al. Nasal NK/T cell lymphoma in Taiwan: a clinicopathologic study of 22 case, with analysis of histologic subtypes, Epstein-Barr virus LMP-1 gene association, and treatment modalities. Int J Surg Pathol, 2004, 12: 375–387.

    Article  PubMed  CAS  Google Scholar 

  28. Wu X, Li P, Zhao J, et al. A clinical study of 115 patients with extranodal natural killer/T-cell lymphoma, nasal type. Clin Oncol (R Coll Radiol), 2008, 20: 619–625.

    Article  CAS  Google Scholar 

  29. Ng SB, Lai KW, Murugaya S, et al. Nasal-type extranodal natural killer/T-cell lymphomas: a clinicopathologic and genotypic study of 42 cases in Singapore. Mod Pathol, 2004, 17: 1097–1107.

    Article  PubMed  Google Scholar 

  30. Altemani A, Barbosa AC, Kulka M, et al. Characteristics of nasal T/NK-cell lymphoma among Brazilians. Neoplasma, 2002, 49: 55–60.

    PubMed  CAS  Google Scholar 

  31. Pagano L, Gallamini A, Trape G, et al. NK/T-cell lymphomas’ nasal type’: an Italian multicentric retrospective survey. Ann Oncol, 2006, 17: 794–800.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Oncology, Mianyang Central Hospital, Mianyang, 621000, China

    Yao Liao & Xiaobo Du

  2. The Second Internal Department, The affiliated Tumor Hospital of Guangzhou Medical College, Guangzhou, 510000, China

    Qingfeng Zou

Authors
  1. Yao Liao
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xiaobo Du
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Qingfeng Zou
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Xiaobo Du.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Liao, Y., Du, X. & Zou, Q. Extranodal natural killer/T-cell lymphoma, nasal type: epidemiology study. Chin. -Ger. J. Clin. Oncol. 11, 290–293 (2012). https://doi.org/10.1007/s10330-012-0962-4

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10330-012-0962-4

Key words

Search

Navigation