Abstract
Objective
The aim of this study was to investigate the expression of BRAF of prostate cancer, and to explore its relations with clinic-pathological factors.
Methods
Immunohistochemistry was used to detect the expression of BRAF in 74 cases of prostate cancer, and 51 cases of benign prostate hyperplasia (BPH).
Results
The positive rate of BRAF had significant difference between patients with prostate cancer and BPH (P < 0.05). The expression of BRAF was correlated with grade and stage of prostate cancer (P < 0.05), but not to age of onset (P > 0.05).
Conclusion
The expression of BRAF may play a role in the tumorigenesis and progression of colorectal cancer. BRAF could be a factor to diagnose the typing of prostate cancers and predict the prognosis of prostate cancers.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
He ZG, Zheng S, Lin DM. Histological types of prostate tumors. J Diag Pathol (Chinese), 2003,10: 316–319.
Zhan YH, Shao Q. The Prostate Surgery, Beijing: People’s Medical Publishing House, 2001. 346–347.
Ikawa S, Fukui M, Ueyama Y, et al. B-raf, a new memberof the raf family is activated by DNA rearrangement. Mol Cell Biol, 1988, 8: 2651–2654.
Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature, 2002, 417: 949–954.
Luo SH, Zhou Y, Gong RX. BRAF and Thyroid Cancer. Modern Prev Med (Chinese), 2007: 64–66.
Mitsutake N, Knauf JA, Mitsutake S, et al. Conditional BRAFV600E expression induces DNA synthesis, apoptosis, dedifferentiation, and chromosomal instability in thyroid PCCL3 cells. Cancer Res, 2005, 65: 2465–2473.
Knauf JA, Ma X, Smith EP, et al. Targeted expression ofBRAFV600E in thyroid cells of transgenic mice results inpapillary thyroid cancers that undergo dedifferentiation. Cancer Res, 2005, 65: 4238–4245.
Yuen ST, davies H, Chan TL, et al. Similarity of the phenotypicpatterns associated with BRAF and KRAS mutations in colorectal neoclassic. Cancer Res, 2004, 62: 6451–6455.
Zhang YX. Expression and its significance of BRAF in colorectal cancers. J Shanxi Med Univ (Chinese), 2008, 39: 798–800.
Houben R, Becker JC, Kappel A, et al. Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis. J Carcinog, 2006, 3: 6–18.
Zhu YY, Si L, Chi ZH. BRAF mutation in Chinese melanoma patients Chin Clin Oncol (Chinese), 2009, 14: 585–588.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Wen, Z., Zou, X., Yang, G. et al. The expression and clinical significance of BRAF in prostate cancer. Chin. -Ger. J. Clin. Oncol. 10, 523–525 (2011). https://doi.org/10.1007/s10330-011-0852-1
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10330-011-0852-1