Abstract
Objective
The aim of the study was to investigate the clinicopathologic significance of caveolin-1 expression in clear cell renal cell carcinoma (CCRCC) and its correlation with microvessel density (MVD).
Methods
The expression of caveolin-1 was detected by the immunohistochemistry method, while the microvessel density was detected by the immunohistochemistry expression of CD34.
Results
In the CCRCCs, the positive rate of caveolin-1 was 67.4%, the over expression of caveolin-1 was not related with sex and age, but related with clinicopathologic parameter, such as tumor sizes, clinical TMN stage, nuclear stage and survival time (P < 0.05). The MVD of positive caveolin-1 cases was significantly higher than that without caveolin-1 expression (P < 0.05).
Conclusion
The expression of caveolin-1 is helpful in the prognostic evaluation of CCRCCs and it may be involved in the tumor angiogenesis.
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Supported by a grant from the Technology Development Foundation of the Pudong New District (No. PKJ2009-Y24).
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Wu, J., Fei, S. & He, Y. Expression of caveolin-1 in clear cell renal cell carcinoma and its correlation with microvessel density. Chin. -Ger. J. Clin. Oncol. 9, 730–733 (2010). https://doi.org/10.1007/s10330-010-0713-3
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DOI: https://doi.org/10.1007/s10330-010-0713-3