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Evaluation of dynamic contrast-enhanced MRI in monitoring early response of locally advanced breast cancer to neoadjuvant chemotherapy

  • Published:
The Chinese-German Journal of Clinical Oncology

Abstract

Objective

The aim of our study was to assess the value of dynamic contrast-enhanced magnetic resonance imaging (DMRI) in predicting early response to neoadjuvant chemotherapy (NAC) in patients with locally advanced breast cancer (LABC) and to assess the accuracy of DMRI in evaluating residual disease after NAC.

Methods

DMRI were performed in 43 women with LABC (44 lesions, all were invasive ductal carcinoma) before, after the first and final cycle of NAC. Tumour volume, early enhanced ratio (E1), maximum enhanced ratio (Emax), and maximum enhanced time (Tmax), dynamic signal intensity-time curve were obtained during treatment. Residual tumour volumes obtained using DMRI were compared with pathological findings to assess the accuracy of DMRI.

Results

After 1st cycle of NAC, the mean volume of responders decreased insignificantly, P > 0.05, but after NAC, mean volume of residual tumor decreased significantly (P < 0.01). Morphology change: 29 cases showed a concentric shrinkage pattern while 7 cases showed a dendritic shrinkage pattern. Significant differences were found in E1, Emax and Tmax between responders and non-responders (P < 0.05). After 1st cycle of NAC, E1, Emax and Tmax of responders changed significantly (P < 0.001); while there is no significant change in non-responders (P > 0.05). After NAC, dynamic signal intensity-time types were changed in responders, and tended to be significantly flattening, while no significant change was found in non-responders. The residual tumour volume correlation coefficient between DMRI and pathology measurements was very high (r = 0.866, P = 0.000).

Conclusion

DMRI is useful to evaluate the early response to NAC in LABC. The presence and volume of residual disease in LABC patients treated with NAC could be accurately evaluated by DMRI.

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Authors and Affiliations

  1. Department of Diagnostic Radiology, Cancer Hospital, Fudan University, Shanghai, 200032, China

    Xiaohong Wang, Weijun Peng, Hongna Tan, Chao Xin & Jian Mao

  2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China

    Xiaohong Wang, Weijun Peng, Hongna Tan, Chao Xin & Jian Mao

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  1. Xiaohong Wang
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  2. Weijun Peng
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  3. Hongna Tan
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  4. Chao Xin
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  5. Jian Mao
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Correspondence to Weijun Peng.

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Wang, X., Peng, W., Tan, H. et al. Evaluation of dynamic contrast-enhanced MRI in monitoring early response of locally advanced breast cancer to neoadjuvant chemotherapy. Chin. -Ger. J. Clin. Oncol. 9, 637–642 (2010). https://doi.org/10.1007/s10330-010-0706-2

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  • DOI: https://doi.org/10.1007/s10330-010-0706-2

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