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Melanotic medullary carcinoma of thyroid: a case report

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The Chinese-German Journal of Clinical Oncology


Melanotic medullary carcinoma is extremely rare. We described a 35-year-old man who was found swelling in the left neck accidently, and no clinic evidences. A left total and right subtotal thyroidectomy and neck lymph nodes dissection were done. Lymph nodes metastasis was not shown. Postoperative of four months, computerized tomography scan liver showed multiple focal lesion. Microscopic examination showed that abundant melanin pigmentation was observed in many of tumor cells. Tumor cells were diffusely immunopositive for vimentin, CK, CgA, syn, CEA, Calcitonin, HMB45, S-100 and negative for TG, TTF-1. Melanotic medullary carcinoma is very rare. It is necessary to report more cases for exact biological behavior and prognosis.

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Correspondence to Guiping Qin.

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Qin, G., Ji, X. Melanotic medullary carcinoma of thyroid: a case report. Chin. -Ger. J. Clin. Oncol. 9, 677–679 (2010).

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