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Neoadjuvant intra-arterial infusion chemotherapy followed by surgery in patients with locally advanced cervical cancer

  • Published:
The Chinese-German Journal of Clinical Oncology

Abstract

Objective

The aim of this study was to investigate the role of pre- operative neoadjuvant intra-arterial infusion chemotherapy (NAIC) in treating locally advanced cervical caner.

Methods

Nineteen locally advanced cervical cancer (LACC) patients from November 2003 to November 2005 were analyzed retrospectively. NAIC was administrated 2 courses every 2 weeks using a combination of 30 mg/m2 bleomycin and 50 mg/m2 cisplatin via bilateral femur arteries. The response to NAIC was assessed by pelvic examination and imaging diagnostics and histological analysis. Two weeks after NAIC radical hysterectomy with pelvic lymphadenectomy was performed.

Results

Radical hysterectomy with pelvic lymphadenectomy were performed in 18 patients successfully. The mean tumor reduction rate was 73.04%. The overall clinical response rate of NAIC was 84.2% with 2 complete responses and 16 partial responses. Only 1 nonresponder. Six of 7 cases who had parametrial infiltration had a absence after chemotherapy, no significant change was observed in 1 case who followed by radiotherapy. Multivariate logistic regression analysis indicated that tumor volume prior to treatment was determining factor affecting the efficacy of NAIC in LACC.

Conclusion

pre-operative NAIC inhibited the growth of LACC, minimized the size, eliminate effectively the pathologic risk factors in the pelvic cavity, to improve the operability in cervical cancer patients with stage IIB or above, considered inoperable.

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Authors and Affiliations

  1. Department of Obstetric and Gynecology, The 3rd People’s Hospital, Chongqing, 400015, China

    Qin Wu

  2. Department of Obstetric and Gynecology, Beijing Hospital, Beijing, 100073, China

    Yi Zhang

Authors
  1. Qin Wu
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  2. Yi Zhang
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Correspondence to Qin Wu.

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Wu, Q., Zhang, Y. Neoadjuvant intra-arterial infusion chemotherapy followed by surgery in patients with locally advanced cervical cancer. Chin. -Ger. J. Clin. Oncol. 8, 537–540 (2009). https://doi.org/10.1007/s10330-009-0108-5

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  • DOI: https://doi.org/10.1007/s10330-009-0108-5

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