Skip to main content

Advertisement

Log in

Expressions and their significance of PTTG and PCNA proteins in glioma

  • Published:
The Chinese-German Journal of Clinical Oncology

Abstract

Objective

To investigate the expressions and their relationship of pituitary tumor transforming gene (PTTG) and proliferating cell nuclear antigen (PCNA) in glioma.

Methods

The protein expressions of PTTG and PCNA were detected by immunostaining assay using streptavidin-peroxidase (SP) method in 80 cases of glioma.

Results

The positive rates of PTTG in grades I–IV gliomas were 56.3%, 68.2%, 80.8%, and 100.0% respectively, and the protein expression of PTTG increased with the increasing of the pathological grade (χ2 = 9.602, P < 0.05); The positive rates of PCNA protein were 37.5%, 54.5%, 69.2%, and 93.8% respectively, and the protein expression of PCNA increased with the increasing of the pathological grade (χ2 = 12.147, P < 0.01). The expression of PTTG had positive correlation with the expression of PCNA protein (γ = 0.557, P < 0.01).

Conclusion

The expressions of PTTG and PCNA proteins were related to malignant degree of glioma, and may cooperate with each other in the tumorigenesis and progression and can be considered as the indicators of the biological behaviors in glioma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Pei L, Melmed S. Isolation and characterization of a pituitary tumor-transforming gene (PTTG). Mol Endocrinol, 1997, 11: 433–441.

    Article  PubMed  CAS  Google Scholar 

  2. Zhang X, Horwitz GA, Heaney AP, et al. Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas. J Clin Endocrinol Metab, 1999, 84: 761–767.

    Article  PubMed  CAS  Google Scholar 

  3. Minematsu T, Suzuki M, Sanno N, et al. PTTG overexpression is correlated with angiogenesis in human pituitary adenomas. Endocr Pathol, 2006, 17: 143–153.

    Article  PubMed  CAS  Google Scholar 

  4. Kim DS, Franklyn JA, Boelaert K, et al. Pituitary tumor transforming gene (PTTG) stimulates thyriod cell proliferation via a vascular endothelial growth factor/kinase insert domain receptor/inhibitor of DNA binding-3 autocrine pathway. J Clin Endocrinol Metab, 2006, 91: 4603–4611.

    Article  PubMed  CAS  Google Scholar 

  5. Yu R, Ren SG, Horwitz GA, et al. Pituitary tumor transforming gene (PTTG) regulates placental JEG-3 cell division and survival: evidence from live cell imaging. Mol Endocrinol, 2000, 14: 1137–1146.

    Article  PubMed  CAS  Google Scholar 

  6. Lin J, Yu FG, Wang XL, et al. The expression and its significance of PTTG gene and Ki67 in gastric carcinoma. Shandong Med J (Chinese), 2005, 45: 12–14.

    Google Scholar 

  7. Wang CH, Feng ZQ. Expression of PTTG gene and PTEN gene in human breast carcinomas. Acta Uni Med Nanjing (Nat Sci) (Chinese), 2005, 25: 20–21.

    Google Scholar 

  8. Solbach C, Roller M, Fellbaum C, et al. PTTG mRNA expression in primary breast cancer: a prognostic marker for lymph node invasion and tumor recurrence. Breast, 2004, 13: 80–81.

    Article  PubMed  Google Scholar 

  9. Zhang ML, Lu S, Zheng SS. Epigenetic changes of pituitary tumor-derived transforming gene 1 in pancreatic cancer. Hepatobiliary Pancreat Dis Int, 2008, 7: 313–317.

    PubMed  CAS  Google Scholar 

  10. Genkai N, Homma J, Sano M, et al. Increased expression of pituitary tumor-transforming (PTTG)-1 is correlated with poor prognosis in glioma patients. Oncol Rep, 2006, 15: 1569–1574.

    PubMed  CAS  Google Scholar 

  11. Cunningham JM, Kimmel DW, Scheithauer BW, et al. Analysis of proliferation markers and p53 expression in gliomas of astrocytic origin: relationships and prognostic value. J Neurosurg, 1997, 86: 121–130.

    Article  PubMed  CAS  Google Scholar 

  12. Verstegen MJ, Leenstra DT, Ijlst-Keizers H, et al. Proliferation- and apoptosis-related proteins in intracranial ependymomas: an immunohistochemical analysis. J Neurooncol, 2002, 56: 21–28.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Rufei Dai.

Additional information

Supported by a grant from the Natural Science Foundation of College and University of Jiangsu Province (No. 05KJD320238).

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dai, R., Zhang, S. Expressions and their significance of PTTG and PCNA proteins in glioma. Chin. -Ger. J. Clin. Oncol. 8, 110–113 (2009). https://doi.org/10.1007/s10330-008-0159-z

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10330-008-0159-z

Key words

Navigation