Abstract
Objective
To research the contribution of ILK and PTEN to the carcinogenesis and development of gastric carcinoma and the relation with anti-oncogene PTEN.
Methods
ILK and PTEN proteins, PTEN mRNA of 76 cases of normal gastric mucous and 112 cases of gastric carcinoma were detected by immunohistochemistry method and in situ hybridization.
Results
The expression of ILK, PTEN protein in gastric carcinoma group and normal gastric mucosa group, muscular layer invasive group and no muscular layer invasive group, lymphatic metastasis group and non-lymphatic metastasis group were all statistical significance (P < 0.05 or P< 0.01). The expression of PTEN mRNA of gastric carcinoma group was lower than that of normal gastric mucosa group (P < 0.01). The expression of ILK and PTEN protein had negative correlation (r = −0.347, P < 0.01).
Conclusion
ILK protein increasing and PTEN protein decreasing have closely relation with the genesis and development of gastric carcinoma, and controlling them may become a new treating target gastric cancer.
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Supported by Sanitary Science and Technological Development Foundation of Shandong Province (2003HW015).
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Wang, Z., Wang, X., Li, J. et al. The expression significance and associativity of ILK and PTEN in gastric cancer tissue. Chin. -Ger. J. Clin. Oncol. 7, 701–703 (2008). https://doi.org/10.1007/s10330-008-0136-6
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DOI: https://doi.org/10.1007/s10330-008-0136-6