Abstract
Objective
To evaluate the therapeutic as well as side effects of hydroxycamptothecin (HCPT) plus FOLFOX4 regimen as salvage therapy for patients with advanced gastric cancer.
Methods
A total of 19 patients with advanced gastric cancer received HCPT plus FOLFOX4 as salvage therapy, in detail, Oxaliplatin 85 mg/m2 was given intravenously on day 1, CF 200 mg/m2, 5-Fu 400 mg/m2 given in bolus immediately after CF, days 1–2; 5-Fu 600 mg/m2 given continuously after bolus for 22 h on day 1, day 2, HCPT given intravenously at dosage of 10 mg/m2 on days 1–2. Therapeutic effects were evaluated at least after two cycles of treatment.
Results
17 cases among the 19 patients were valid for response evaluation, with CR 1, PR 6, SD 4, PD 6. The response rate was 41.2%. For the 12 patients with liver metastasis, response rate of the liver foci was 50%. The main toxicities were bone marrow suppression, nausea and vomiting, and peripheral neuropathy; there were no chemotherapy-related deaths.
Conclusion
The combination regimen with HCPT plus FOFLOX4 regimen was effective as salvage therapy for patients with advanced gastric cancer, with particularly high response rate for liver metastasis, and the side effects were tolerable and manageable.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Chen ZW, Liao ML. Evaluation of tumor response with RECIST criteria. Bull Chin Cancer (Chinese), 2004, 13: 616–618.
Qin SK, Gon XL. Current status and progress on advanced gastric cancer. Chin Clin Oncol (Chinese), 2006, 11: 641–652.
Zhou XJ, Fan XQ, Li XY, et al. Clinical analysis of 21 cases of progressive GI tumors treated with XELOX. Chin Clin Oncol (Chinese), 2007, 12: 211–212.
Patiyil S, Alberts SR. Metastatic colorectal cancer: therapeutic options. Curr Treat Options Oncol, 2006, 7: 389–398.
Cavanna L, Artioli F, Codignola C, et al. Oxaliplatin in combination with 5-fluorouracil (5-Fu) and leucovorin (LV) in patients with metastatic gastric cancer (MGC). Am J Clin Oncol, 2006, 29: 371–375.
Mei JF, Qin SK, Qian J, et al. Study of oxaliplatin combined with 5-fluorouracil and folinic acid (FOLFOX4 regimen) as second line treatment for the patients with advanced gastric cancer. Cancer Res Prevent Treat (Chinese), 2005, 32: 440–441.
Sun YJ, Zhao H, Guo YW, et al. Short-term effects of chemotherapy with combination of hydroxycamptothecine and oxaliplatin in the treatment of advanced digestive tract cancers. Chin J Oncol (Chinese), 2004, 26: 749–752.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Fan, X., Zhou, X., Li, X. et al. Clinical analysis of HCPT plus FOLFOX4 regimen as salvage therapy for patients with advanced gastric cancer. Chin. -Ger. J. Clin. Oncol. 7, 698–700 (2008). https://doi.org/10.1007/s10330-008-0115-y
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10330-008-0115-y