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Investigation of the relationship between DNA-dependent protein kinase and lymphatic metastasis in colorectal cancer

  • Published:
The Chinese-German Journal of Clinical Oncology

Abstract

Objective

To investigate DNA-dependent protein kinase (DNA-PK) expression, and its relationship with lymphatic metastasis in colorectal cancer.

Methods

Tumor tissues from 60 patients, divided into two groups according to lymphatic metastasis, were immunohistochemically stained to detect the DNA-PK expression including Ku70, Ku80 and PKcs proteins.

Results

Positivity of both Ku70 and Ku80 in colorectal cancer was negatively correlated with lymphatic metastasis with an r value of −0.57 and −0.38, respectively. Similar correlation was found between Ku expression, especially Ku70, and long-term survival. PKcs, however, displayed no significant correlation. Statistical analysis failed to detect any correlation between DNAPK expression, and clinical characteristics, such as age, sex, tumor location, tumor thickness and distant metastasis (P > 0.05).

Conclusion

DNA-PK expression, especially Ku70 expression, is negatively correlated with lymphatic metastasis, and the survival of patients with colorectal cancer. Ku70 expression may be a potential indicator for the preoperative evaluation, and prognosis in colorectal cancer.

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Authors and Affiliations

  1. Department of General Surgery, Jiading Branch of Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, 201800, China

    Yueyu Chen, Zhaohui Liu, Kun Zhu & Yuelong Wu

  2. Department of Surgery, Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, 201800, China

    Haoran Yin

Authors
  1. Yueyu Chen
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  2. Zhaohui Liu
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  3. Kun Zhu
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  4. Yuelong Wu
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  5. Haoran Yin
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Corresponding author

Correspondence to Yueyu Chen.

Additional information

Supported by a grant from the Scientific Research Project of the Bureau of Health of Jiading in Shanghai (No. KYXM-2004-11-07).

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Chen, Y., Liu, Z., Zhu, K. et al. Investigation of the relationship between DNA-dependent protein kinase and lymphatic metastasis in colorectal cancer. Chin. -Ger. J. Clin. Oncol. 7, 348–351 (2008). https://doi.org/10.1007/s10330-008-0036-9

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  • DOI: https://doi.org/10.1007/s10330-008-0036-9

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