Abstract
Objective
To study the relationship between expressions of α-, β-catenins and cyclin D1 and the occurrence, infiltration and metastasis of breast cancer.
Methods
High sensitive S-P immunohistochemical method was used to detect the protein expressions of α-, β-catenins and cyclin D1 in the 60 cases of breast cancer tissues.
Results
Abnormal immunoreactivities of α-and β-catenins were observed in 37 (61.7%) and 42 (70%) cases of breast cancer tissues, respectively. There were 28 cases (46.7%) who showed cyclin D1 overexpression. The abnormal expression rates of α-and β-catenins in infiltrating lobular carcinoma (ILC) were significantly higher than those in infiltrating ductal carcinoma (IDC) (P < 0.05), but they had no relations to the extent of differentiation and lymphatic metastasis of breast cancer (P > 0.05). The overexpression rate of cyclin D1 was correlated with tumor stage and lymphatic metastasis of breast cancer (P < 0.05), but not with histological type and the extent of differentiation (P > 0.05). Cyclin D1 overexpression was observed in 57.1% (24/42) of these cases that showed abnormal staining of β-catenin, but only observed in 22.2% (4/18) of these cases with normal membranous staining of β-catenin. There was a significantly positive correlation between the abnormal expression of β-catenin and overexpression of cyclin D1 (r s = 0.321, P < 0.05).
Conclusion
The abnormal expression of β-catenin may play an important role in the genesis of breast cancer by triggering cyclin D1 overexpression in breast cancer. The abnormal expressions of α-and β-catenins are not a key factor in malignant cell metastasis in breast cancer, but may also involve in the progress.
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References
Cui J, Zhou XD, Liu YS. Wnt pathway and neoplasm. Fore Med Sci Cancer Sect (Chinese), 2000, 27: 138–140.
Lim SC, Lee MS. Significance of E-cadherin/beta-catenin complex and cyclin D1 in breast cancer. Oncol Rep, 2002, 9: 915–928.
Lin SY, Xia W, Wang JC, et al. Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proc Natl Acad Sci USA, 2000, 97: 4262–4266.
Gonzalez MA, Pinder SE, Wencyk PM, et al. An immunohistochemical examination of the expression of E-cadherin, alpha-and beta/gamma-catenins, and alpha2-and beta1-integrins in invasive breast cancer. J Pathol, 1999, 187: 523–529.
Maruyama K, Ochiai A, Akimoto S, et al. Cytoplasmic beta-catenin accumulation as a predictor of hematogenous metastasis in human colorectal cancer. Oncology, 2000, 59: 302–309.
Ishikawa T, Furihata M, Ohtsuki Y, et al. Cyclin D1 overexpression related to retinoblastoma protein expression as a prognostic marker in human oesophageal squamous cell carcinoma. Br J Cancer, 1998, 77: 92–97.
Li Z, Lin SX, Liang YJ. Detection of gene promoter methylation and mRNA, protein expression levels of E-cadherin in nasopharyngeal carcinoma. Chin J Pathol (Chinese), 2003, 32: 25–30.
Li YJ, Ji XR. Relationship between the expression of β-cat, cyclin D1 and c-myc and the occurrence and biological behavior of pancreatic cancer. Chin J Pathol (Chinese), 2003, 32: 238–241.
Saito T, Oda Y, Sakamoto A, et al. Prognostic value of the preserved expression of the E-cadherin and catenin families of adhesion molecules and of beta-catenin mutations in synovial sarcoma. J Pathol, 2000, 192: 342–350.
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Zeng, L., Chen, S., Liu, Z. et al. The expressions and significance of α-, β-catenins and cyclin D1 in breast cancers. Chin. -Ger. J. Clin. Oncol. 7, 335–338 (2008). https://doi.org/10.1007/s10330-008-0033-z
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DOI: https://doi.org/10.1007/s10330-008-0033-z