Skip to main content
SpringerLink
Log in

Expression and clinical implication of p27 and p57 in cutaneous squamous cell carcinoma and Bowen’s disease

  • Published:
The Chinese-German Journal of Clinical Oncology

Abstract

Objective

To investigate the expression and clinical significance of cyclin dependent kinase inhibitors p27 and p57 in cutaneous squamous cell carcinoma and Bowen’s disease.

Methods

The expression of p27 and p57 were evaluated in 10 normal skin tissues, 25 Bowen’s disease (BD) and 30 cutaneous squamous cell carcinoma (SCC) with immunohistochemistrical staining.

Results

The levels of p27 protein expression in SCC were dramatically lower than those in normal skin and BD (P < 0.05). The levels of p57 protein expression in SCC were dramatically lower than those in normal skin and BD (P < 0.05). There was a positive correlation between p27 and p57 (r = 0.469, P < 0.05).

Conclusion

The decrease of p27 and skp2 may be used for considering the biological behavior of human cutaneous squamous cell carcinoma and Bowen’s disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Zhang DM, Shen AG. P27kip: The positive/negative bi-directional control mechanism of cell cycle. J Clin Oncol (Chinese), 2005, 10:211–213.

    Google Scholar 

  2. Qu CJ, Shi TX, Lin GM, et al. The expression of p27 and cyclin E in Bowen’s disease and squamous cell carcinoma. Chin J Dermatol (Chinese), 2006, 39: 71–73.

    CAS  Google Scholar 

  3. Du J, Tu P, Liu GY, et al. Expression of P27 and cyclin D1 in keratinocyte-derived tumors. Chin J Dermatol (Chinese), 2001, 34: 271–273.

    CAS  Google Scholar 

  4. Man XH, Wang JB, Liu YH, et al. Cyclin E, p27 in the Pathogenesis of External Genital Epidermal Tumors. Chin J Dermatol (Chinese), 2004, 37: 419–421.

    CAS  Google Scholar 

  5. Shen H, Xu AE. P27, cyclin E and p21 in keratoacanthoma the expression of tumor lesions. Chin J Dermatol (Chinese), 2002, 35: 51–52.

    Google Scholar 

  6. Fan GK, Xu FZ, Yang BB, et al. p57(kip2) expression is related to carcinogenesis and tumor progression in laryngeal tissues. Acta Otolaryngol, 2006, 126: 301–305.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Hong Liang & Jiawen Li

  2. Department of Dermatology, Xiangfan Central Hospital, Xiangfan, 441003, China

    Dingdan Tian

Authors
  1. Hong Liang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jiawen Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Dingdan Tian
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jiawen Li.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Liang, H., Li, J. & Tian, D. Expression and clinical implication of p27 and p57 in cutaneous squamous cell carcinoma and Bowen’s disease. Chin. -Ger. J. Clin. Oncol. 7, 176–178 (2008). https://doi.org/10.1007/s10330-007-0152-y

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10330-007-0152-y

Key words

Search

Navigation