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Effect of controlled low central venous pressure on renal function in major liver resection

The Chinese-German Journal of Clinical Oncology volume 7, pages 7–9 (2008)Cite this article

Abstract

Objective

To investigate the effects of low central venous pressure (LVCP) on blood loss and evaluate its influence on renal function in patients undergoing hepatectomy.

Methods

Forty-six patients, ASA classification I-III, undergoing liver resection were randomized into LCVP group (n = 23) and control group (n = 23). In LCVP group, CVP was maintained at 2–4 mmHg and MBP above 60 mmHg during hepatectomy, while in control group hepatectomy was performed routinely without lowering CVP. Volume of blood loss during hepatectomy, volume of blood transfusion, and changes of renal functions were compared between the two groups.

Results

There were no significant differences in demographics, ASA score, type of hepatectomy, duration of inflow occlusion, operation time, weight of resected liver tissues, and renal functions between the two groups. LCVP group had a significantly lower volume of total intraoperative blood loss (P < 0.01) and RBC transfusion (P < 0.05).

Conclusion

Lowering the CVP to less than 5 mmHg is a simple and effective technique to reduce blood loss and blood infusion during liver resection, and has no detrimental effects on renal functions.

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Authors and Affiliations

  1. Department of Anesthesia, The First Affiliated Hospital, Jinan University, Guangzhou, 510630, China

    Yuyong Liu, Mingxue Cai, Shan’e Duan, Xuemei Peng, Yong Lai & Yalan Li

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  1. Yuyong Liu
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  2. Mingxue Cai
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  3. Shan’e Duan
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  4. Xuemei Peng
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  5. Yong Lai
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  6. Yalan Li
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Correspondence to Yuyong Liu.

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Liu, Y., Cai, M., Duan, S. et al. Effect of controlled low central venous pressure on renal function in major liver resection. Chin. -Ger. J. Clin. Oncol. 7, 7–9 (2008). https://doi.org/10.1007/s10330-007-0128-y

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  • DOI: https://doi.org/10.1007/s10330-007-0128-y

Key words

  • hepatectomy
  • hepatocellular carcinoma
  • low central venous pressure
  • blood loss
  • renal function