Abstract
Objective: To investigate the anti-leukemic function of econazole (Ec), an azole anti-fungal drug. Methods: We compared efficacy of econazole to induce apoptosis in HL-60 cells with two other known endoplasmic reticulum (ER) stress inducer thapsigargin (Tg) and tunicamycin (Tu). Results: Cells treated with Ec showed typical morphology of apoptosis following 24 h incubation, parallel to the morphological changes, the expression of molecular chaperone GRP 78 was up-regulated in all cases and the caspase 12, an ER resident caspase was activated. Conclusion: Ec induced ER stress related apoptosis in HL-60 cells; the underlying mechanisms are protein synthesis inhibition through elF2a phosphorylation and caspase 12 activation.
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Hu, Z., Liu, W., Berger, S. et al. A preliminary study on the econazole induced endoplasmic reticulum related apoptosis in HL-60 leukemic cells. Chinese German J Clin Oncol 5, 376–378 (2006). https://doi.org/10.1007/s10330-005-0435-0
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DOI: https://doi.org/10.1007/s10330-005-0435-0