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Experimental Study on Apoptosis in Leukemia Cells Induced by Econazole

  • Original Paper
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The Chinese-German Journal of Clinical Oncology

Abstract

Objective: To investigate apoptosis in mouse leukemia cell (WEHI-3) induced by Econazole and its mechanism. Methods: Apoptosis induced by Econazole was examined by flow cytometry. Free calcium ([Ca2+]i) was determined by Fura-2 fluorescein load technique. The protein was isolated from endoplasmic reticulum of WEHI-3 cells, and then the expression of caspase-12 and caspase-7 was detected by Western blot. Results: WEHI-3 cells exhibited typical change of apoptosis when they were treated by Econazole. [Ca2+]i was significantly higher in Econazole-treated group than in control group. The expression of caspase-12 and caspase-7 was increased with the increase of Econazole concentration. Conclusion: Caspase-12 may play a key role in WEHI-3 apoptosis induced by Econazole.

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Authors and Affiliations

  1. Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, China

    LIU Fang, ZOU Ping, ZHANG Min, WU Yaohui & XIAO Juan

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  1. LIU Fang
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  2. ZOU Ping
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  3. ZHANG Min
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  4. WU Yaohui
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  5. XIAO Juan
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Correspondence to LIU Fang.

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LIU, F., ZOU, P., ZHANG, M. et al. Experimental Study on Apoptosis in Leukemia Cells Induced by Econazole. Chinese-German J Clin Oncol 4, 102–104 (2005). https://doi.org/10.1007/s10330-004-0292-2

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  • DOI: https://doi.org/10.1007/s10330-004-0292-2

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