Abstract
Objective: To study the relationship between the expression of E-cadherin and microvessel density (MVD) in lung cancer. Methods: The expression of E-cadherin and factor VIII was detected in 104 lung cancer tissues by an immunohistochemical method, and MVD was calculated by an image- analysis system. Results: The expression of E-cadherin was significantly related to the differentiation of lung cancers (P<0.05). A negative correlation was found between E-cadherin expression and MVD in lung cancer tissues (P=0.047). Conclusion: Down-expression of E-cadherin and an increase of MVD may play an important role in the invasion and metastasis of lung cancer, and may also be used as a useful marker for tumor prognosis.
Similar content being viewed by others
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
WANG, X., YANG, J., MA, Y. et al. Relationship between the Expression of E-cadherin and Microvessel Density in Lung Cancer and Its Significance. Chinese-German J Clin Oncol 4, 99–101 (2005). https://doi.org/10.1007/s10330-004-0253-9
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s10330-004-0253-9