Abstract
Objective: To evaluate the apoptosis positivity, the expression of Bcl-2, bax proteins in 30 patients with squamous cell cervix carcinoma before and after radiotherapy. Methods: By using immunohistochemical and TDT-dUTP nick end labelling techniques, 30 cases of squamous cell cervical carcinoma were analyzed. Results: The apoptosis positivity before and after irradiation was 76.7% and 100% respectively, with the difference being significant (P<0.05); The positive rates of Bcl-2 protein before and after irradiation were 73.3% and 46.7% respectively, with the difference being significant (P<0.05); The positive rates of bax protein before and after irradiation were 86% and 100% respectively, with the difference being significant (P<0.05). Conclusion: bax and Bcl-2 protein play an important role in apoptosis induced by fractionated radiation therapy. Apoptosis induced by irradiation is contributed to upregulation of bax protein or downregulation of Bcl-2 protein.
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ZHAO, D., SHI, J., LI, M. et al. The Expression of Apoptosis-Related Genes Bcl-2 and Bax Protein and Apoptosis Positivity in Cervical Carcinoma during Irradiation. Chinese-German J Clin Oncol 4, 105–107 (2005). https://doi.org/10.1007/s10330-004-0220-5
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DOI: https://doi.org/10.1007/s10330-004-0220-5