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Chimpanzee Down syndrome: a case study of trisomy 22 in a captive chimpanzee

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We report a case of chimpanzee trisomy 22 in a captive-born female. Because chromosome 22 in great apes is homologous to human chromosome 21, the present case is analogous to human trisomy 21, also called Down syndrome. The chimpanzee in the present case experienced retarded growth; infantile cataract and vision problems, including nystagmus, strabismus, and keratoconus; congenital atrial septal defect; and hypodontia. All of these symptoms are common in human Down syndrome. This case was the second reported case of trisomy 22 in the chimpanzee. The chimpanzee in our case became blind by 7 years old, making social life with other chimpanzees difficult, but opportunities to interact with other conspecific individuals have been offered routinely. We believe that providing her with the best care over the course of her life will be essential.

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  • Andrle M, Fiedler W, Rett A, Ambros P, Schweizer D (1979) A case of trisomy 22 in Pongo pygmaeus. Cytogenet Genome Res 24:1–6

    Article  CAS  Google Scholar 

  • Antonarakis SE, Lyle R, Dermitzakis ET, Reymond A, Deutsch S (2004) Chromosome 21 and down syndrome: from genomics to pathophysiology. Nat Rev Gen 5:725–738

    Article  CAS  Google Scholar 

  • Bull MJ (2011) Health supervision for children with Down syndrome. Pediatrics 128:393–406

    Article  PubMed  Google Scholar 

  • Down JLH (1866) Observations on an ethnic classification of idiots. Lond Hosp Rep 3:259–262

    Google Scholar 

  • Dutrillaux B (1979) Chromosomal evolution in primates: tentative phylogeny from Microcebus murinus (Prosimian) to man. Human Genet 48:251–314

    Article  CAS  Google Scholar 

  • Gavan JA (1952) Birth order and birth weight in the chimpanzee. Am J Phys Anthropol 10:23–30

    Article  CAS  PubMed  Google Scholar 

  • Hamada Y, Udono T, Teramoto M, Sugawara T (1996) The growth pattern of chimpanzees: somatic growth and reproductive maturation in Pan troglodytes. Primates 37:279–295

    Article  Google Scholar 

  • Hayashi M, Sakuraba Y, Watanabe S, Kaneko A, Matsuzawa T (2013) Behavioral recovery from tetraparesis in a captive chimpanzee. Primates 54:237–243

    Article  PubMed  Google Scholar 

  • Hernandez D, Fisher EM (1996) Down syndrome genetics: unravelling a multifactorial disorder. Hum Mol Gen 5:1411–1416

    Article  CAS  PubMed  Google Scholar 

  • Hirai H, Hasegawa Y, Kawamoto Y, Tokita E (1998) Tandem duplication of nucleolus organizer region (NOR) in the Japanese macaque, Macaca fuscata fuscata. Chromosome Res 6:191–197

    Article  CAS  PubMed  Google Scholar 

  • Hirai H, Mootnick AR, Takenaka O, Suryobroto B, Mouri T, Kamanaka Y, Katoh A, Kimura N, Katoh A, Maeda N (2003) Genetic mechanism and property of a whole-arm translocation (WAT) between chromosomes 8 and 9 of agile gibbons (Hylobates agilis). Chromosome Res 11:37–50

    Article  CAS  PubMed  Google Scholar 

  • Howell S, Hoffman K, Bartel L, Schwandt M, Morris J, Fritz J (2003) Normal hematologic and serum clinical chemistry values for captive chimpanzees (Pan troglodytes). Comp Med 53:413–423

    CAS  PubMed  Google Scholar 

  • Jacobs P, Brown WC, Baikie AG, Strong JA (1959) The somatic chromosomes in mongolism. Lancet 273:710

    Article  Google Scholar 

  • Jauch A, Wienberg J, Stanyon R, Arnold N, Tofanelli S, Ishida T, Cremer T (1992) Reconstruction of genomic rearrangements in great apes and gibbons by chromosome painting. Proc Natl Acad Sci USA 89:8611–8615

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lejeune J, Gautier M, Turpin R (1959) Etude des chromosomes somatiques de neuf enfants mongoliens. Compte Rendu d’Acad Sci 248:1721–1722

    CAS  Google Scholar 

  • Luke S, Gandhi S, Verma RS (1995) Conservation of the Down syndrome critical region in humans and great apes. Gene 161:283–285

    Article  CAS  PubMed  Google Scholar 

  • Matsumoto T, Itoh N, Inoue S, Nakamura M (2016) An observation of a severely disabled infant chimpanzee in the wild and her interactions with her mother. Primates 57:3–7

    Article  PubMed  Google Scholar 

  • Matsuzawa T (2016) Euthanasia is not an option: 10 years’ care of a chimpanzee with acute tetraparesis. Primates 57:291–293

    Article  PubMed  Google Scholar 

  • McClure HM, Belden KH, Pieper WA, Jacobson CB (1969) Autosomal trisomy in a chimpanzee: resemblance to Down’s syndrome. Science 165:1010–1012

    Article  CAS  PubMed  Google Scholar 

  • Miyabe-Nishiwaki T, Kaneko A, Nishiwaki K, Watanabe A, Watanabe S, Maeda N, Kumazaki K, Morimoto M, Hirokawa R, Suzuki J, Ito Y, Hayashi M, Tanaka M, Tomonaga M, Matsuzawa T (2010) Tetraparesis resembling acute transverse myelitis in a captive chimpanzee (Pan troglodytes): long-term care and recovery. J Med Primatol 39:336–346

    Article  CAS  PubMed  Google Scholar 

  • Morimura N, Gen’ichi I, Matsuzawa T (2011) The first chimpanzee sanctuary in Japan: an attempt to care for the “surplus” of biomedical research. Am J Primatol 73:226–232

    Article  PubMed  Google Scholar 

  • Richard F, Dutrillaux B (1998) Origin of human chromosome 21 and its consequences: a 50-million-year-old story. Chromosome Res 6:263–268

  • Ried T, Arnold N, Ward DC, Wienberg J (1993) Comparative high-resolution mapping of human and primate chromosomes by fluorescence in situ hybridization. Genomics 18:381–386

    Article  CAS  PubMed  Google Scholar 

  • Sakuraba Y, Tomonaga M, Hayashi M (2016) A new method of walking rehabilitation using cognitive tasks in an adult chimpanzee (Pan troglodytes) with a disability: a case study. Primates 57:403–412. doi:10.1007/s10329-016-0541-3

    Article  PubMed  Google Scholar 

  • Turleau C, de Grouchy J, Klein M (1972) Phylogenie chromosomique de I’homme et des primates hominiens (Pan troglodytes, Gorilla gorilla, et Pongo pygmaeus): essai dereconstitution du caryotypes de I’ancestre commun. Ann Genet 15:225–240

    CAS  PubMed  Google Scholar 

  • Watanuki K, Ochiai T, Hirata S, Morimura N, Tomonaga M, Idani G, Matsuzawa T (2014) Review and long-term survey of the status of captive chimpanzees in Japan in 1926–2013. (in Japanese with English summary). Primate Res 30:147–156

    Article  Google Scholar 

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We have complied with the ethical standards in the treatment of the chimpanzees with the guidelines of the Primate Society of Japan. We thank the staff at Kumamoto Sanctuary for support in caring for the chimpanzees. The care of the chimpanzees and the present study was financially supported by JSPS grant #23220006, 26245069, 25119008, 242550099, 15H05709, 16H06301, 16H06283, JSPS-LGP-U04, JSPS core-to-core CCSN.

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Correspondence to Satoshi Hirata.

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Hirata, S., Hirai, H., Nogami, E. et al. Chimpanzee Down syndrome: a case study of trisomy 22 in a captive chimpanzee. Primates 58, 267–273 (2017).

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