Skip to main content

Identification and characterization of host factors involved in plant RNA virus replication

This is a preview of subscription content, access via your institution.


  1. Castro B, Citterico M, Kimura S, Stevens DM, Wrzaczek M, Coaker G (2021) Stress-induced reactive oxygen species compartmentalization, perception and signalling. Nat Plants 7(4):403–412

    CAS  Article  Google Scholar 

  2. Chuang C, Barajas D, Qin J, Nagy PD (2014) Inactivation of the host lipin gene accelerates RNA virus replication through viral exploitation of the expanded endoplasmic reticulum membrane. PLoS Pathog 10(2):e1003944

    Article  Google Scholar 

  3. Hong Y, Zhao J, Guo L, Kim SC, Deng X, Wang G, Zhang G, Li M, Wang X (2016) Plant phospholipases D and C and their diverse functions in stress responses. Prog Lipid Res 62:55–74

    CAS  Article  Google Scholar 

  4. Hyodo K, Okuno T (2016) Pathogenesis mediated by proviral host factors involved in translation and replication of plant positive-strand RNA viruses. Curr Opin Virol 17:11–18

    CAS  Article  Google Scholar 

  5. Hyodo K, Okuno T (2020) Hijacking of host cellular components as proviral factors by plant-infecting viruses. Adv Virus Res 107:37–86

    Article  Google Scholar 

  6. Hyodo K, Kaido M (2021) Dianthovirus (Tombusviridae). In: Bamford D, Zuckerman M (eds) Encyclopedia of virology, vol 3, 4th edn. Elsevier, Amsterdam, pp 383–387

    Chapter  Google Scholar 

  7. Hyodo K, Taniguchi T, Manabe Y, Kaido M, Mise K, Sugawara T, Taniguchi H, Okuno T (2015) Phosphatidic acid produced by phospholipase D promotes RNA replication of a plant RNA virus. PLoS Pathog 11(5):e1004909

    Article  Google Scholar 

  8. Hyodo K, Hashimoto K, Kuchitsu K, Suzuki N, Okuno T (2017a) Harnessing host ROS-generating machinery for the robust genome replication of a plant RNA virus. Proc Natl Acad Sci USA 114(7):E1282–E1290

    CAS  Article  Google Scholar 

  9. Hyodo K, Suzuki N, Mise K, Okuno T (2017b) Roles of superoxide anion and hydrogen peroxide during replication of two unrelated plant RNA viruses in Nicotiana benthamiana. Plant Signal Behav 12(6):e1338223

    Article  Google Scholar 

  10. Hyodo K, Suzuki N, Okuno T (2019) Hijacking a host scaffold protein, RACK1, for replication of a plant RNA virus. New Phytol 221(2):935–945

    CAS  Article  Google Scholar 

  11. Ketter E, Randall G (2019) Virus impact on lipids and membranes. Annu Rev Virol 6(1):319–340

    CAS  Article  Google Scholar 

  12. Lee CC, Lin TL, Lin JW, Han YT, Huang YT, Hsu YH, Meng M (2016) Promotion of Bamboo Mosaic Virus Accumulation in Nicotiana benthamiana by 5’→3’ Exonuclease NbXRN4. Front Microbiol 6:1508

    PubMed  PubMed Central  Google Scholar 

  13. Otulak-Kozieł K, Kozieł E, Bujarski JJ, Frankowska-Łukawska J, Torres MA (2020) Respiratory burst oxidase homologs RBOHD and RBOHF as key modulating components of response in turnip mosaic virus-Arabidopsis thaliana (L.) Heyhn system. Int J Mol Sci 21(22):8510

    Article  Google Scholar 

  14. Wang A (2015) Dissecting the molecular network of virus-plant interactions: the complex roles of host factors. Annu Rev Phytopathol 53:45–66

    CAS  Article  Google Scholar 

  15. Zhang Z, He G, Han GS, Zhang J, Catanzaro N, Diaz A, Wu Z, Carman GM, Xie L, Wang X (2018) Host Pah1p phosphatidate phosphatase limits viral replication by regulating phospholipid synthesis. PLoS Pathog 14(4):e1006988

    Article  Google Scholar 

  16. Zhang Z, He G, Filipowicz NA, Randall G, Belov GA, Kopek BG, Wang X (2019) Host lipids in positive-strand RNA virus genome replication. Front Microbiol 10:286

    CAS  Article  Google Scholar 

Download references


I am deeply grateful to Dr. Tetsuro Okuno, Dr. Kazuyuki Mise, Dr. Masanori Kaido, and Dr. Yoshitaka Takano at Kyoto University, and Dr. Nobuhiro Suzuki and Dr. Hideki Kondo at Institute of Plant Science and Resources (IPSR), Okayama University, for their valuable suggestions, support, and warm encouragement. I also appreciate my colleagues and collaborators for their help and encouragement. My research was supported by the Japan Society for the Promotion of Science KAKENHI Grant (15H06420, 17K15229, 17H05818, 19K15841, 19H04836, and 21H02198).

Author information



Corresponding author

Correspondence to Kiwamu Hyodo.

Ethics declarations

Conflict of interest

The author has no conflict of interest to declare.

Ethical approval

This article does not contain any experiments performed with human participants or animals.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is an abstract of the paper presented by a winner of the Young Scientist Award at the 2021 Annual Meeting of the Phytopatho logical Society of Japan in Mie (online).

About this article

Verify currency and authenticity via CrossMark

Cite this article

Hyodo, K. Identification and characterization of host factors involved in plant RNA virus replication. J Gen Plant Pathol 87, 415–417 (2021).

Download citation