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Role of microbes, metabolites and effector compounds in host–microbiota interaction: a pharmacological outlook


Microbial cells react with intestinal surfaces and produce enzymes and metabolites that influence human health, host metabolism and immunity. Gut microbiota and probiotics also influence host physiology. Here, we review 1) the role of host–microbiota composition and microbial enzymes in human well-being and in human metabolism for the degradation of indigestible dietary components; 2) the effects of gut microbiota on drug metabolism; 3) the roles of probiotic composition, metabolites, e.g. vitamins, bacteriocins, acids and bioactive peptides, and effector compounds, e.g. polysaccharides, outer membrane proteins, pili, muropeptides and CpG-rich DNA, for clinical outcomes; and 4) a new perspective of microbial global positioning system (mGPS) for segregation of human disease phenotypes on the basis of their microbiota.

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This work was the result of two financial grants from Department of Science and Technology (DST), India, for individual research projects to be implemented at BAS department, NIFTEM: (1) BB acknowledges the funding from Science and Engineering Research Board under DST-SERB NPDF scheme (financial sanction # PDF/2018/003949), and (2) MK acknowledges the financial approval from DST-KIRAN division under WOS-A scheme [financial approval # SR/WOS-A/CS-41/2017 (G)].

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Correspondence to Bharat Bhushan or Brij Pal Singh.

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Bhushan, B., Singh, B.P., Saini, K. et al. Role of microbes, metabolites and effector compounds in host–microbiota interaction: a pharmacological outlook. Environ Chem Lett 17, 1801–1820 (2019).

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  • Microbiota
  • Probiotics
  • Metabolites
  • Effector molecules
  • Pharmacology
  • Drug metabolism