Synthesis of quinoxalines using Gum Arabic as a nontoxic metal-free biocatalyst at room temperature in aqueous media
- 58 Downloads
In the present study, Gum Arabic was used as a metal-free biocatalyst in the synthesis of quinoxaline derivatives through condensation of 1,2-diamines and 1,2-dicarbonyl compounds at room temperature under aqueous media. The advantages of the present protocol included the appropriate reaction times, high yields, and environmental friendliness. The structure of products was approved by FT-IR and 1H-NMR spectroscopy.
KeywordsGum Arabic 1,2-Diamines 1,2-Diketones Quinoxalines Biocatalyst
The work was supported by grant from the Research Council of Yazd University, Yazd, Iran. The authors declare that they have no conflicts of interest.
- Abu-Hashem AA (2015) Synthesis, reactions and biological activity of quinoxaline derivatives. Am J Org Chem 5(1):14–56Google Scholar
- Fahimi N, Sardarian AR, Kazemnejadi M (2016) Vitamin C as a green and efficient catalyst in synthesis of quinoxaline derivatives at room temperature. Iran J Catal 6(2):161–166Google Scholar
- Ingle RG, Marathe RP (2012) Review on literature study of quinoxaline. Pharmacophore 3(2):109–116Google Scholar
- Kattumuri V, KattiK Bhaskaran S, Boote EJ, Casteel SW, Fent GM, Robertson DJ, Chandrasekhar M, Kannan R, Katti KV (2007) Gum Arabic as a phytochemical construct for the stabilization of gold nanoparticles: in vivo pharmacokinetics and X-ray-contrast-imaging studies. Small 3(2):333–341CrossRefGoogle Scholar
- Petronijević J, Bugarčić Z, Bogdanović GA, Stefanović S, Janković N (2017) An enolate ion as a synthon in biocatalytic synthesis of 3,4-dihydro-2(1H)-quinoxalinones and 3,4-dihydro-1,4-benzoxazin-2-ones: lemon juice as an alternative to hazardous solvents and catalysts. Green Chem 19(3):707–715CrossRefGoogle Scholar
- Pradeep K, Kotra V, Priyadarshini RL, Pratap V (2015) Synthesis, characterization and anti-inflammatory activity of novel quinoxaline derived chalcones. Int J Pharm Pharm Sci 7(1):243–246Google Scholar
- Raju BC, Ramachandra K (2012) La (OTf)3 catalysed synthesis of quinoxaline. Indian J Chem 51B:756–759Google Scholar
- Sadeghi B, Karimi F (2013) ZnO nanoparticles as an efficient and reusable catalyst for synthesis of quinoxaline under solvent free condition. Iran J Catal 3(1):1–7Google Scholar
- Tarpada UP, Thummar BB, Raval DK (2013) A green protocol for the synthesis of quinoxaline derivatives catalyzed by polymer supported sulphanilic acid. Arab J Chem (in press)Google Scholar