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Ecofriendly synthesis of 3-cyanopyridine derivatives by multi-component reaction catalyzed by animal bone meal

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Abstract

Green organic synthesis is needed to face current environmental pollution. Many synthetic approaches have been developed to produce substituted cyanopyridines. However, only a few green methods are reported. This article reports a simple and convenient synthesis of substituted pyridines by one-pot multi-component reaction of 1,3-dicarbonyl compounds, aromatic aldehydes, malononitrile and alcohols, catalyzed by doped animal bone meal as catalyst. The reaction has several advantages such as high yields of 80–92 %, short reaction times of 10–15 min, easy purification processes and methodological simplicity.

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Acknowledgments

The authors thank the “Volubilis” Hubert Curien Program for financial support.

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Authors and Affiliations

  1. Laboratoire de Biochimie, Environnement and Agroalimentaire, URAC 36, Université Hassan II Mohammedia-Casablanca, Mohammedia, Morocco

    Yassine Riadi & Saïd Lazar

  2. UMR CNRS 7311, Institut de Chimie Organique and Analytique, Université d’Orléans, Orléans, France

    Yassine Riadi, Sylvain Routier & Gérald Guillaumet

  3. Laboratoire de Chimie Bio-Organique Appliquée, Université Ibn Zohr, Agadir, Morocco

    Rachid Mamouni

Authors
  1. Yassine Riadi
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  2. Rachid Mamouni
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  3. Sylvain Routier
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  4. Gérald Guillaumet
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  5. Saïd Lazar
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Correspondence to Gérald Guillaumet or Saïd Lazar.

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Riadi, Y., Mamouni, R., Routier, S. et al. Ecofriendly synthesis of 3-cyanopyridine derivatives by multi-component reaction catalyzed by animal bone meal. Environ Chem Lett 12, 523–527 (2014). https://doi.org/10.1007/s10311-014-0478-y

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  • DOI: https://doi.org/10.1007/s10311-014-0478-y

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